T00008
type: Enzyme
cath: Butyryl-Coa Dehydrogenase, subunit A; domain 1
cath: Butyryl-CoA Dehydrogenase, subunit A; domain 2
cath: Butyryl-CoA Dehydrogenase, subunit A; domain 3
ec: https://purl.uniprot.org/enzyme/1.3.8.7
csa: 3mdd
uniprot: Q72JJ3
uniprot: Q5SGZ2
uniprot: P41367
uniprot: P11310
kegg enzyme: medium-chain acyl-CoA dehydrogenase
kegg pathway: Fatty acid metabolism
kegg pathway: Valine, leucine and isoleucine degradation
kegg pathway: beta-Alanine metabolism
kegg pathway: Propanoate metabolism
kegg cofactor: FAD
kegg substrate: Acyl-CoA
kegg substrate: Electron-transferring flavoprotein
kegg product: 2,3-Dehydroacyl-CoA
kegg product: Reduced electron-transferring flavoprotein
pdb: 1ukwA01
pdb: 1ukwB01
pdb: 2cx9A01
pdb: 2cx9B01
pdb: 2cx9C01
pdb: 2cx9D01
pdb: 1udyA01
pdb: 1udyB01
pdb: 1udyC01
pdb: 1udyD01
pdb: 3mddA01
pdb: 3mddB01
pdb: 3mdeA01
pdb: 3mdeB01
pdb: 1egcA01
pdb: 1egcB01
pdb: 1egcC01
pdb: 1egcD01
pdb: 1egdA01
pdb: 1egdB01
pdb: 1egdC01
pdb: 1egdD01
pdb: 1egeA01
pdb: 1egeB01
pdb: 1egeC01
pdb: 1egeD01
pdb: 1t9gA01
pdb: 1t9gB01
pdb: 1t9gC01
pdb: 1t9gD01
pdb: 2a1tA01
pdb: 2a1tB01
pdb: 2a1tC01
pdb: 2a1tD01
pdb: 1ukwA02
pdb: 1ukwB02
pdb: 2cx9A02
pdb: 2cx9B02
pdb: 2cx9C02
pdb: 2cx9D02
pdb: 1udyA02
pdb: 1udyB02
pdb: 1udyC02
pdb: 1udyD02
pdb: 3mddA02
pdb: 3mddB02
pdb: 3mdeA02
pdb: 3mdeB02
pdb: 1egcA02
pdb: 1egcB02
pdb: 1egcC02
pdb: 1egcD02
pdb: 1egdA02
pdb: 1egdB02
pdb: 1egdC02
pdb: 1egdD02
pdb: 1egeA02
pdb: 1egeB02
pdb: 1egeC02
pdb: 1egeD02

Butyryl-Coa Dehydrogenase, subunit A; domain 1
type: Cath
references: http://www.cathdb.info/version/latest/superfamily/1.10.540.10

Butyryl-CoA Dehydrogenase, subunit A; domain 2
type: Cath
references: http://www.cathdb.info/version/latest/superfamily/2.40.110.10

Butyryl-CoA Dehydrogenase, subunit A; domain 3
type: Cath
references: http://www.cathdb.info/version/latest/superfamily/1.20.140.10
catalytic domain: index.html

Fatty acid metabolism
type: KeggPathway
references: KEGG:MAP00071

Valine, leucine and isoleucine degradation
type: KeggPathway
references: KEGG:MAP00280

beta-Alanine metabolism
type: KeggPathway
references: KEGG:MAP00410

Propanoate metabolism
type: KeggPathway
references: KEGG:MAP00640

FAD
type: KeggCofactor
references: KEGG:C00016
compound type: amide group
compound type: amine group
compound type: aromatic ring (only carbon atom)
compound type: aromatic ring (with nitrogen atoms)
compound type: carbohydrate
compound type: nucleotide
references: CHEBI:16238
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi

Acyl-CoA
type: KeggSubstrate
references: KEGG:C00040
compound type: amine group
compound type: carbohydrate
compound type: nucleotide
compound type: peptide/protein
compound type: sulfide group

Electron-transferring flavoprotein
type: KeggSubstrate
references: KEGG:C04253
compound type: amide group
compound type: amine group
compound type: aromatic ring (only carbon atom)
compound type: aromatic ring (with nitrogen atoms)
compound type: carbohydrate
compound type: peptide/protein
compound type: phosphate group/phosphate ion

2,3-Dehydroacyl-CoA
type: KeggProduct
references: KEGG:C00605
compound type: amine group
compound type: carbohydrate
compound type: nucleotide
compound type: peptide/protein
compound type: sulfide group

Reduced electron-transferring flavoprotein
type: KeggProduct
references: KEGG:C04570
compound type: amide group
compound type: amine group
compound type: aromatic ring (only carbon atom)
compound type: aromatic ring (with nitrogen atoms)
compound type: carbohydrate
compound type: peptide/protein
compound type: phosphate group/phosphate ion

1ukwA03
type: Pdb
references: 1ukw
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ukw
catalytic residue: GLU 393
main chain in catalysis: GLU 393

1ukwB03
type: Pdb
references: 1ukw
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ukw
catalytic residue: GLU 393
main chain in catalysis: GLU 393

2cx9A03
type: Pdb
references: 2cx9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2cx9
catalytic residue: GLU 369
main chain in catalysis: GLU 369

2cx9B03
type: Pdb
references: 2cx9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2cx9
catalytic residue: GLU 369
main chain in catalysis: GLU 369

2cx9C03
type: Pdb
references: 2cx9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2cx9
catalytic residue: GLU 369
main chain in catalysis: GLU 369

2cx9D03
type: Pdb
references: 2cx9
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2cx9
catalytic residue: GLU 369
main chain in catalysis: GLU 369

1udyA03
type: Pdb
references: 1udy
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1udy
catalytic residue: GLU 376
main chain in catalysis: GLU 376

1udyB03
type: Pdb
references: 1udy
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1udy
catalytic residue: GLU 376
main chain in catalysis: GLU 376

1udyC03
type: Pdb
references: 1udy
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1udy
catalytic residue: GLU 376
main chain in catalysis: GLU 376

1udyD03
type: Pdb
references: 1udy
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1udy
catalytic residue: GLU 376
main chain in catalysis: GLU 376

3mddA03
type: Pdb
references: 3mdd
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:3mdd
catalytic residue: GLU 376
main chain in catalysis: GLU 376

3mddB03
type: Pdb
references: 3mdd
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:3mdd
catalytic residue: GLU 376
main chain in catalysis: GLU 376

3mdeA03
type: Pdb
references: 3mde
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:3mde
catalytic residue: GLU 376
main chain in catalysis: GLU 376

3mdeB03
type: Pdb
references: 3mde
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:3mde
catalytic residue: GLU 376
main chain in catalysis: GLU 376

1egcA03
type: Pdb
references: 1egc
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1egc
comment: mutant T255E, E376G

1egcB03
type: Pdb
references: 1egc
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1egc
comment: mutant T255E, E376G

1egcC03
type: Pdb
references: 1egc
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1egc
comment: mutant T255E, E376G

1egcD03
type: Pdb
references: 1egc
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1egc
comment: mutant T255E, E376G

1egdA03
type: Pdb
references: 1egd
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1egd
comment: mutant T255E, E376G

1egdB03
type: Pdb
references: 1egd
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1egd
comment: mutant T255E, E376G

1egdC03
type: Pdb
references: 1egd
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1egd
comment: mutant T255E, E376G

1egdD03
type: Pdb
references: 1egd
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1egd
comment: mutant T255E, E376G

1egeA03
type: Pdb
references: 1ege
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ege
catalytic residue: GLU 376
main chain in catalysis: GLU 376
comment: mutant T255E

1egeB03
type: Pdb
references: 1ege
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ege
catalytic residue: GLU 376
main chain in catalysis: GLU 376
comment: mutant T255E

1egeC03
type: Pdb
references: 1ege
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ege
catalytic residue: GLU 376
main chain in catalysis: GLU 376
comment: mutant T255E

1egeD03
type: Pdb
references: 1ege
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ege
catalytic residue: GLU 376
main chain in catalysis: GLU 376
comment: mutant T255E

1t9gA03
type: Pdb
references: 1t9g
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1t9g
catalytic residue: GLU 376
main chain in catalysis: GLU 376

1t9gB03
type: Pdb
references: 1t9g
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1t9g
catalytic residue: GLU 376
main chain in catalysis: GLU 376

1t9gC03
type: Pdb
references: 1t9g
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1t9g
catalytic residue: GLU 376
main chain in catalysis: GLU 376

1t9gD03
type: Pdb
references: 1t9g
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1t9g
catalytic residue: GLU 376
main chain in catalysis: GLU 376

2a1tA03
type: Pdb
references: 2a1t
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2a1t
catalytic residue: GLU 376
main chain in catalysis: GLU 376

2a1tB03
type: Pdb
references: 2a1t
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2a1t
catalytic residue: GLU 376
main chain in catalysis: GLU 376

2a1tC03
type: Pdb
references: 2a1t
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2a1t
catalytic residue: GLU 376
main chain in catalysis: GLU 376

2a1tD03
type: Pdb
references: 2a1t
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2a1t
catalytic residue: GLU 376
main chain in catalysis: GLU 376

Analogue
compound: Acyl-CoA
pdb: 1udyA03
ligand het code: CS8

Analogue
compound: Acyl-CoA
pdb: 1udyB03
ligand het code: CS8

Analogue
compound: Acyl-CoA
pdb: 1udyC03
ligand het code: CS8

Analogue
compound: Acyl-CoA
pdb: 1udyD03
ligand het code: CS8

ReferenceForCatalyticMechanism
reference index: 1
reference section: Scheme 2

ReferenceForCatalyticMechanism
reference index: 4
reference section: p.417

ReferenceForCatalyticMechanism
reference index: 15
reference section: p.7525-7527

ReferenceForCatalyticMechanism
reference index: 19
reference section: Scheme 1

ReferenceForCatalyticMechanism
reference index: 21
reference section: Scheme 3, p.719, p.722-723

ReferenceForCatalyticMechanism
reference index: 22
reference section: Fig.10, Fig.11, p.805-807

ReferenceForCatalyticMechanism
reference index: 24
reference section: p.12417-12420

ReferenceForCatalyticMechanism
reference index: 30
reference section: Scheme 1

ReferenceForCatalyticMechanism
reference index: 31
reference section: Fig.4, p.14609-14612

ReferenceForCatalyticMechanism
reference index: 32
reference section: p.1701-1704

ReferenceForCatalyticMechanism
reference index: 35
reference section: Scheme 1, Scheme 2, Scheme 5, p.8443-8444

ReferenceForCatalyticMechanism
reference index: 36
reference section: p.8454

ReferenceForCatalyticMechanism
reference index: 37
reference section: Scheme 1, p.1856-1860

ReferenceForCatalyticMechanism
reference index: 38
reference section: Fig.1, Fig.3

ReferenceForCatalyticMechanism
reference index: 39
reference section: Fig.1, p.226

ReferenceForCatalyticMechanism
reference index: 40
reference section: Scheme 4, p.264-266

ReferenceForCatalyticMechanism
reference index: 41
reference section: Scheme 1, Fig.7

ReferenceForCatalyticMechanism
reference index: 42
reference section: Scheme 2, p.13989-13991

ReferenceForCatalyticMechanism
reference index: 45
reference section: Scheme 1

ReferenceForCatalyticMechanism
reference index: 50
reference section: Scheme 1, p.4638

ReferenceForCatalyticMechanism
reference index: 50
reference section: Fig.8, p.4645-4647

ReferenceForCatalyticMechanism
reference index: 53
reference section: Scheme 1, Scheme 2, p.11852-11855

ReferenceForCatalyticMechanism
reference index: 54
reference section: p.301-303

ReferenceForCatalyticMechanism
reference index: 55
reference section: p.488-491

ReferenceForCatalyticMechanism
reference index: 56

ReferenceForCatalyticMechanism
reference index: 58
reference section: Fig.5

Spiropentaneacetic acid as a specific inhibitor of medium-chain acyl-CoA dehydrogenase.
type: BibliographicResource
comment: T00007-5
references: http://www.ncbi.nlm.nih.gov/pubmed/1931995
journal: Biochemistry
volume: 30
pages: 10755-60
published year: 1991
authors:
  item: Tserng KY
  item: Jin SJ
  item: Hoppel CL

http://ezcatdb.cbrc.jp/EzCatDB/reference/T00008#1
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/3968064
journal: J Biol Chem
volume: 260
pages: 1326-37
published year: 1985
authors:
  item: Ikeda Y
  item: Hine DG
  item: Okamura-Ikeda K
  item: Tanaka K
title: Mechanism of action of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases. Direct evidence for carbanion formation as an intermediate step using enzyme-catalyzed C-2 proton/deuteron exchange in the absence of C-3 exchange.

Studies on the reaction mechanism of general acyl-CoA dehydrogenase. Determination of selective isotope effects in the dehydrogenation of butyryl-CoA.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/3769916
journal: Eur J Biochem
volume: 160
pages: 109-15
published year: 1986
authors:
  item: Pohl B
  item: Raichle T
  item: Ghisla S

Preferential cross-linking of the small subunit of the electron-transfer flavoprotein to general acyl-CoA dehydrogenase.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/3115254
journal: Biochem J
volume: 243
pages: 519-24
published year: 1987
authors:
  item: Steenkamp DJ

Acyl-CoA dehydrogenases, electron transfer flavoprotein and electron transfer flavoprotein dehydrogenase.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/3053288
journal: Biochem Soc Trans
volume: 16
pages: 416-8
published year: 1988
authors:
  item: Frerman FE

Structure of the medium-chain acyl-CoA dehydrogenase from pig liver mitochondria at 3-A resolution.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/3413116
journal: Proc Natl Acad Sci U S A
volume: 85
pages: 6677-81
published year: 1988
authors:
  item: Kim JJ
  item: Wu J

Characterization of wild-type and an active site mutant of human medium chain acyl-CoA dehydrogenase after expression in Escherichia coli.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/1970566
journal: J Biol Chem
volume: 265
pages: 7116-9
published year: 1990
authors:
  item: Bross P
  item: Engst S
  item: Strauss AW
  item: Kelly DP
  item: Rasched I
  item: Ghisla S

Molecular characterization of inherited medium-chain acyl-CoA dehydrogenase deficiency.
type: BibliographicResource
comment: VARIANT MCAD GLU-329.
medline id: 91067682
references: http://www.ncbi.nlm.nih.gov/pubmed/2251268
journal: Proc Natl Acad Sci U S A
volume: 87
pages: 9236-40
published year: 1990
authors:
  item: Kelly DP
  item: Whelan AJ
  item: Ogden ML
  item: Alpers R
  item: Zhang ZF
  item: Bellus G
  item: Gregersen N
  item: Dorland L
  item: Strauss AW
references: P11310

Structural studies of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/2326312
journal: Prog Clin Biol Res
volume: 321
pages: 569-76
published year: 1990
authors:
  item: Kim JJ
  item: Wu J

http://ezcatdb.cbrc.jp/EzCatDB/reference/T00008#10
type: BibliographicResource
comment: VARIANT MCAD GLU-329.
medline id: 91224627
references: http://www.ncbi.nlm.nih.gov/pubmed/1902818
journal: Hum Genet
volume: 86
pages: 545-51
published year: 1991
authors:
  item: Gregersen N
  item: Andresen BS
  item: Bross P
  item: Winter V
  item: Rudiger N
  item: Engst S
  item: Christensen E
  item: Kelly D
  item: Strauss AW
  item: Kolvraa S
  item: et al
title: Molecular characterization of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency: identification of a lys329 to glu mutation in the MCAD gene, and expression of inactive mutant enzyme protein in E. coli.
references: P11310

http://ezcatdb.cbrc.jp/EzCatDB/reference/T00008#11
type: BibliographicResource
comment: T00007-6
references: http://www.ncbi.nlm.nih.gov/pubmed/8102510
journal: Am J Hum Genet
volume: 53
pages: 730-9
published year: 1993
authors:
  item: Andresen BS
  item: Bross P
  item: Jensen TG
  item: Winter V
  item: Knudsen I
  item: Kolvraa S
  item: Jensen UB
  item: Bolund L
  item: Duran M
  item: Kim JJ
  item: et al
title: A rare disease-associated mutation in the medium-chain acyl-CoA dehydrogenase (MCAD) gene changes a conserved arginine, previously shown to be functionally essential in short-chain acyl-CoA dehydrogenase (SCAD).

Microscopic pathway for the medium-chain fatty acyl CoA dehydrogenase catalyzed oxidative half-reaction: changes in the electronic structures of flavin and CoA derivatives during catalysis.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/8218225
journal: Biochemistry
volume: 32
pages: 11575-85
published year: 1993
authors:
  item: Johnson JK
  item: Kumar NR
  item: Srivastava DK

Detection and identification of a chromophoric intermediate during the medium-chain fatty acyl-CoA dehydrogenase-catalyzed reaction via rapid-scanning UV/visible spectroscopy.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/8267794
journal: Biochemistry
volume: 32
pages: 8004-13
published year: 1993
authors:
  item: Johnson JK
  item: Srivastava DK

13C- and 15N-NMR studies on medium-chain acyl-CoA dehydrogenase reconstituted with 13C- and 15N-enriched flavin adenine dinucleotide.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/8454567
journal: J Biochem (Tokyo)
volume: 113
pages: 106-13
published year: 1993
authors:
  item: Miura R
  item: Nishina Y
  item: Sato K
  item: Fujii S
  item: Kuroda K
  item: Shiga K

Crystal structures of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria with and without substrate.
type: BibliographicResource
comment: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
medline id: 93361479
references: http://www.ncbi.nlm.nih.gov/pubmed/8356049
journal: Proc Natl Acad Sci U S A
volume: 90
pages: 7523-7
published year: 1993
authors:
  item: Kim JJ
  item: Wang M
  item: Paschke R
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: P41367

Molecular basis of the medium-chain fatty acyl-CoA dehydrogenase-catalyzed "oxidase" reaction: pH-dependent distribution of intermediary enzyme species during catalysis.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/8161532
journal: Biochemistry
volume: 33
pages: 4738-44
published year: 1994
authors:
  item: Johnson JK
  item: Kumar NR
  item: Srivastava DK

Intramitochondrial folding and assembly of medium-chain acyl-CoA dehydrogenase (MCAD). Demonstration of impaired transfer of K304E-variant MCAD from its complex with hsp60 to the native tetramer.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/7905878
journal: J Biol Chem
volume: 269
pages: 4401-8
published year: 1994
authors:
  item: Saijo T
  item: Welch WJ
  item: Tanaka K

Medium-chain acyl-CoA dehydrogenase- and enoyl-CoA hydratase-dependent bioactivation of 5,6-dichloro-4-thia-5-hexenoyl-CoA.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/7703241
journal: Biochemistry
volume: 34
pages: 4276-86
published year: 1995
authors:
  item: Fitzsimmons ME
  item: Thorpe C
  item: Anders MW

Oxidative inactivation of a charge transfer complex in the medium-chain acyl-CoA dehydrogenase.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/8845370
journal: Biochemistry
volume: 34
pages: 16424-32
published year: 1995
authors:
  item: Schaller RA
  item: Thorpe C

http://ezcatdb.cbrc.jp/EzCatDB/reference/T00008#20
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/7718565
journal: Biochemistry
volume: 34
pages: 4625-32
published year: 1995
authors:
  item: Srivastava DK
  item: Kumar NR
  item: Peterson KL
title: "Dehydrogenase" and "oxidase" reactions of medium-chain fatty acyl-CoA dehydrogenase utilizing chromogenic substrates: role of the 3',5'-adenosine diphosphate moiety of the coenzyme A thioester in catalysis.

Structure and mechanism of action of the acyl-CoA dehydrogenases.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/7601336
journal: FASEB J
volume: 9
pages: 718-25
published year: 1995
authors:
  item: Thorpe C
  item: Kim JJ

Structural modulation of 2-enoyl-CoA bound to reduced acyl-CoA dehydrogenases: a resonance Raman study of a catalytic intermediate.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/7592542
journal: J Biochem (Tokyo)
volume: 117
pages: 800-8
published year: 1995
authors:
  item: Nishina Y
  item: Sato K
  item: Hazekawa I
  item: Shiga K

Effects of two mutations detected in medium chain acyl-CoA dehydrogenase (MCAD)-deficient patients on folding, oligomer assembly, and stability of MCAD enzyme.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/7730333
journal: J Biol Chem
volume: 270
pages: 10284-90
published year: 1995
authors:
  item: Bross P
  item: Jespersen C
  item: Jensen TG
  item: Andresen BS
  item: Kristensen MJ
  item: Winter V
  item: Nandy A
  item: Krautle F
  item: Ghisla S
  item: Bolundi L
  item: et al

Crystal structures of the wild type and the Glu376Gly/Thr255Glu mutant of human medium-chain acyl-CoA dehydrogenase: influence of the location of the catalytic base on substrate specificity.
type: BibliographicResource
comment: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
medline id: 96420477
references: http://www.ncbi.nlm.nih.gov/pubmed/8823176
journal: Biochemistry
volume: 35
pages: 12412-20
published year: 1996
authors:
  item: Lee HJ
  item: Wang M
  item: Paschke R
  item: Nandy A
  item: Ghisla S
  item: Kim JJ
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: P11310

Medium-long-chain chimeric human Acyl-CoA dehydrogenase: medium-chain enzyme with the active center base arrangement of long-chain Acyl-CoA dehydrogenase.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/8823175
journal: Biochemistry
volume: 35
pages: 12402-11
published year: 1996
authors:
  item: Nandy A
  item: Kieweg V
  item: Krautle FG
  item: Vock P
  item: Kuchler B
  item: Bross P
  item: Kim JJ
  item: Rasched I
  item: Ghisla S

Functional role of a distal (3'-phosphate) group of CoA in the recombinant human liver medium-chain acyl-CoA dehydrogenase-catalysed reaction.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9271097
journal: Biochem J
volume: 325
pages: 751-60
published year: 1997
authors:
  item: Peterson KL
  item: Srivastava DK

Medium-chain acyl CoA dehydrogenase: evidence for phosphorylation.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9426198
journal: Biol Chem
volume: 378
pages: 1381-5
published year: 1997
authors:
  item: Macheroux P
  item: Sanner C
  item: Buttner H
  item: Kieweg V
  item: Ruterjans H
  item: Ghisla S

Structure of D-amino acid oxidase: new insights from an old enzyme.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9434899
journal: Curr Opin Struct Biol
volume: 7
pages: 804-10
published year: 1997
authors:
  item: Mattevi A
  item: Vanoni MA
  item: Curti B

Biochemical characterization of purified, human recombinant Lys304-->Glu medium-chain acyl-CoA dehydrogenase containing the common disease-causing mutation and comparison with the normal enzyme.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9208949
journal: Eur J Biochem
volume: 246
pages: 548-56
published year: 1997
authors:
  item: Kieweg V
  item: Krautle FG
  item: Nandy A
  item: Engst S
  item: Vock P
  item: Abdel-Ghany AG
  item: Bross P
  item: Gregersen N
  item: Rasched I
  item: Strauss A
  item: Ghisla S

Elimination reactions in the medium-chain acyl-CoA dehydrogenase: bioactivation of cytotoxic 4-thiaalkanoic acids.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9477967
journal: Biochemistry
volume: 37
pages: 1383-93
published year: 1998
authors:
  item: Baker-Malcolm JF
  item: Haeffner-Gormley L
  item: Wang L
  item: Anders MW
  item: Thorpe C

Redox properties of human medium-chain acyl-CoA dehydrogenase, modulation by charged active-site amino acid residues.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9772189
journal: Biochemistry
volume: 37
pages: 14605-12
published year: 1998
authors:
  item: Mancini-Samuelson GJ
  item: Kieweg V
  item: Sabaj KM
  item: Ghisla S
  item: Stankovich MT

Influence of excision of a methylene group from Glu-376 (Glu376-->Asp mutation) in the medium chain acyl-CoA dehydrogenase-catalyzed reaction.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9484241
journal: Biochemistry
volume: 37
pages: 1697-705
published year: 1998
authors:
  item: Peterson KL
  item: Galitz DS
  item: Srivastava DK

http://ezcatdb.cbrc.jp/EzCatDB/reference/T00008#33
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9730839
journal: Biochemistry
volume: 37
pages: 12659-71
published year: 1998
authors:
  item: Peterson KL
  item: Peterson KM
  item: Srivastava DK
title: Thermodynamics of ligand binding and catalysis in human liver medium-chain acyl-CoA dehydrogenase: comparative studies involving normal and 3'-dephosphorylated C8-CoAs and wild-type and Asn191 --> Ala (N191A) mutant enzymes.

Energetics of two-step binding of a chromophoric reaction product, trans-3-indoleacryloyl-CoA, to medium-chain acyl-coenzyme-A dehydrogenase.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9521671
journal: Biochemistry
volume: 37
pages: 3499-508
published year: 1998
authors:
  item: Qin L
  item: Srivastava DK

Protonic equilibria in the reductive half-reaction of the medium-chain acyl-CoA dehydrogenase.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9622495
journal: Biochemistry
volume: 37
pages: 8437-45
published year: 1998
authors:
  item: Rudik I
  item: Ghisla S
  item: Thorpe C

Discriminatory influence of Glu-376-->Asp mutation in medium-chain acyl-CoA dehydrogenase on the binding of selected CoA-ligands: spectroscopic, thermodynamic, kinetic, and model building studies.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9622496
journal: Biochemistry
volume: 37
pages: 8446-56
published year: 1998
authors:
  item: Srivastava DK
  item: Peterson KL

Substrate activation by acyl-CoA dehydrogenases: transition-state stabilization and pKs of involved functional groups.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9485310
journal: Biochemistry
volume: 37
pages: 1848-60
published year: 1998
authors:
  item: Vock P
  item: Engst S
  item: Eder M
  item: Ghisla S

Structure/function of medium chain acyl-CoA dehydrogenase: the importance of substrate polarization.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/10496972
journal: Arch Biochem Biophys
volume: 370
pages: 16-21
published year: 1999
authors:
  item: Stankovich MT
  item: Sabaj KM
  item: Tonge PJ

Biochemical characterization of a variant human medium-chain acyl-CoA dehydrogenase with a disease-associated mutation localized in the active site.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9882619
journal: Biochem J
volume: 337
pages: 225-30
published year: 1999
authors:
  item: Kuchler B
  item: Abdel-Ghany AG
  item: Bross P
  item: Nandy A
  item: Rasched I
  item: Ghisla S

Mechanism of activation of acyl-CoA substrates by medium chain acyl-CoA dehydrogenase: interaction of the thioester carbonyl with the flavin adenine dinucleotide ribityl side chain.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9890906
journal: Biochemistry
volume: 38
pages: 257-67
published year: 1999
authors:
  item: Engst S
  item: Vock P
  item: Wang M
  item: Kim JJ
  item: Ghisla S

Mechanism for the recognition and activation of substrate in medium-chain acyl-CoA dehydrogenase.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9990125
journal: J Biochem (Tokyo)
volume: 125
pages: 285-96
published year: 1999
authors:
  item: Tamaoki H
  item: Nishina Y
  item: Shiga K
  item: Miura R

Medium-chain acyl-coenzyme A dehydrogenase bound to a product analogue, hexadienoyl-coenzyme A: effects on reduction potential, pK(a), and polarization.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/11076541
journal: Biochemistry
volume: 39
pages: 13982-92
published year: 2000
authors:
  item: Pellett JD
  item: Sabaj KM
  item: Stephens AW
  item: Bell AF
  item: Wu J
  item: Tonge PJ
  item: Stankovich MT

Influence of alpha-CH-->NH substitution in C8-CoA on the kinetics of association and dissociation of ligands with medium chain acyl-CoA dehydrogenase.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/11027146
journal: Biochemistry
volume: 39
pages: 12659-70
published year: 2000
authors:
  item: Peterson KM
  item: Gopalan KV
  item: Srivastava DK

Energetic consequences of accommodating a bulkier ligand at the active site of medium chain acyl-CoA dehydrogenase by creating a complementary enzyme site cavity.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/11027148
journal: Biochemistry
volume: 39
pages: 12678-87
published year: 2000
authors:
  item: Peterson KM
  item: Srivastava DK

4-Hydroxycinnamoyl-CoA: an ionizable probe of the active site of the medium chain acyl-CoA dehydrogenase.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/10625483
journal: Biochemistry
volume: 39
pages: 92-101
published year: 2000
authors:
  item: Rudik I
  item: Bell A
  item: Tonge PJ
  item: Thorpe C

Flavoenzymes: diverse catalysts with recurrent features.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/10694883
journal: Trends Biochem Sci
volume: 25
pages: 126-32
published year: 2000
authors:
  item: Fraaije MW
  item: Mattevi A

Thioester enolate stabilization in the acyl-CoA dehydrogenases: the effect of 5-deaza-flavin substitution.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/11488611
journal: Arch Biochem Biophys
volume: 392
pages: 341-8
published year: 2001
authors:
  item: Rudik I
  item: Thorpe C

Interaction of 3,4-dienoyl-CoA thioesters with medium chain acyl-CoA dehydrogenase: stereochemistry of inactivation of a flavoenzyme.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/11591145
journal: Biochemistry
volume: 40
pages: 12266-75
published year: 2001
authors:
  item: Wang W
  item: Fu Z
  item: Zhou JZ
  item: Kim JJ
  item: Thorpe C

Molecular and functional characterisation of mild MCAD deficiency.
type: BibliographicResource
comment: VARIANT MCAD LEU-245.
medline id: 21302532
references: http://www.ncbi.nlm.nih.gov/pubmed/11409868
journal: Hum Genet
volume: 108
pages: 404-8
published year: 2001
authors:
  item: Zschocke J
  item: Schulze A
  item: Lindner M
  item: Fiesel S
  item: Olgemoller K
  item: Hoffmann GF
  item: Penzien J
  item: Ruiter JP
  item: Wanders RJ
  item: Mayatepek E
references: P11310

Beyond the proton abstracting role of Glu-376 in medium-chain acyl-CoA dehydrogenase: influence of Glu-376-->Gln substitution on ligand binding and catalysis.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/11926826
journal: Biochemistry
volume: 41
pages: 4638-48
published year: 2002
authors:
  item: Gopalan KV
  item: Srivastava DK

Three-dimensional structure of the flavoenzyme acyl-CoA oxidase-II from rat liver, the peroxisomal counterpart of mitochondrial acyl-CoA dehydrogenase.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/11872165
journal: J Biochem (Tokyo)
volume: 131
pages: 365-74
published year: 2002
authors:
  item: Nakajima Y
  item: Miyahara I
  item: Hirotsu K
  item: Nishina Y
  item: Shiga K
  item: Setoyama C
  item: Tamaoki H
  item: Miura R

Comparison of ligand polarization and enzyme activation in medium- and short-chain acyl-coenzyme A dehydrogenase-novel analog complexes.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/12504892
journal: Arch Biochem Biophys
volume: 409
pages: 251-61
published year: 2003
authors:
  item: Lamm TR
  item: Kohls TD
  item: Saenger AK
  item: Stankovich MT

Probing hydrogen-bonding interactions in the active site of medium-chain acyl-CoA dehydrogenase using Raman spectroscopy.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/14529297
journal: Biochemistry
volume: 42
pages: 11846-56
published year: 2003
authors:
  item: Wu J
  item: Bell AF
  item: Luo L
  item: Stephens AW
  item: Stankovich MT
  item: Tonge PJ

http://ezcatdb.cbrc.jp/EzCatDB/reference/T00008#54
type: BibliographicResource
comment: X|ray crystallography
references: http://www.ncbi.nlm.nih.gov/pubmed/12966080
journal: J Biochem (Tokyo)
volume: 134
pages: 297-304
published year: 2003
authors:
  item: Satoh A
  item: Nakajima Y
  item: Miyahara I
  item: Hirotsu K
  item: Tanaka T
  item: Nishina Y
  item: Shiga K
  item: Tamaoki H
  item: Setoyama C
  item: Miura R
title: Structure of the transition state analog of medium-chain acyl-CoA dehydrogenase. Crystallographic and molecular orbital studies on the charge-transfer complex of medium-chain acyl-CoA dehydrogenase with 3-thiaoctanoyl-CoA.
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl

Acyl-CoA dehydrogenases and acyl-CoA oxidases. Structural basis for mechanistic similarities and differences.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/14728675
journal: Eur J Biochem
volume: 271
pages: 483-93
published year: 2004
authors:
  item: Kim JJ
  item: Miura R

Extensive domain motion and electron transfer in the human electron transferring flavoprotein.medium chain Acyl-CoA dehydrogenase complex.
type: BibliographicResource
comment: X|ray crystallography
references: http://www.ncbi.nlm.nih.gov/pubmed/15159392
journal: J Biol Chem
volume: 279
pages: 32904-12
published year: 2004
authors:
  item: Toogood HS
  item: van Thiel A
  item: Basran J
  item: Sutcliffe MJ
  item: Scrutton NS
  item: Leys D
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl

Expression and purification of His-tagged rat mitochondrial medium-chain acyl-CoA dehydrogenase wild-type and Arg256 mutant proteins.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/15358373
journal: Protein Expr Purif
volume: 37
pages: 472-8
published year: 2004
authors:
  item: Zeng J
  item: Li D

Stabilization of non-productive conformations underpins rapid electron transfer to electron-transferring flavoprotein.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/15975918
journal: J Biol Chem
volume: 280
pages: 30361-6
published year: 2005
authors:
  item: Toogood HS
  item: van Thiel A
  item: Scrutton NS
  item: Leys D
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl

fatty acyl coenzyme A dehydrogenase (ambiguous)
type: KeggEnzyme

acyl coenzyme A dehydrogenase (ambiguous)
type: KeggEnzyme

acyl dehydrogenase (ambiguous)
type: KeggEnzyme

fatty-acyl-CoA dehydrogenase (ambiguous)
type: KeggEnzyme

acyl CoA dehydrogenase (ambiguous)
type: KeggEnzyme

general acyl CoA dehydrogenase (ambiguous)
type: KeggEnzyme

medium-chain acyl-coenzyme A dehydrogenase
type: KeggEnzyme

acyl-CoA:(acceptor) 2,3-oxidoreductase (ambiguous)
type: KeggEnzyme

ACADM (gene name)
type: KeggEnzyme