M00331
type: Enzyme
rlcp: p1162
cath: http://ezcatdb.cbrc.jp/EzCatDB/cath/-.-.-.-
cath: Immunoglobulin-like
cath: Phosphorylase Kinase; domain 1
cath: Transferase(Phosphotransferase); domain 1
ec: https://purl.uniprot.org/enzyme/2.7.10.1
uniprot: P36888
kegg enzyme: Receptor protein-tyrosine kinase
kegg enzyme: ATP:protein-tyrosine O-phosphotransferase (ambiguous)
kegg enzyme: CD135
kegg enzyme: CDw135
kegg enzyme: FLK1
kegg enzyme: FLK2
kegg enzyme: FLT1
kegg enzyme: FLT2
kegg enzyme: FLT3
kegg enzyme: FLT4
kegg enzyme: FMS
kegg enzyme: Fv2
kegg enzyme: Protein-tyrosine kinase (ambiguous)
kegg enzyme: Protein tyrosine kinase (ambiguous)
kegg enzyme: Receptor protein tyrosine kinase
kegg enzyme: STK
kegg enzyme: STK1
kegg cofactor: Mg
kegg substrate: ATP
kegg substrate: [protein]-L-tyrosine
kegg product: ADP
kegg product: [protein]-L-tyrosine phosphate
pdb: 3qs7E01
pdb: 3qs7F01
pdb: 3qs9E01
pdb: 3qs9G01
pdb: 3qs9H01
pdb: 3qs7E02
pdb: 3qs7F02
pdb: 3qs7G01
pdb: 3qs7H01
pdb: 3qs9E02
pdb: 3qs9G02
pdb: 3qs9H02
pdb: 3qs9F01
pdb: 3qs7E03
pdb: 3qs7F03
pdb: 3qs7G02
pdb: 3qs7H02
pdb: 3qs9E03
pdb: 3qs9G03
pdb: 3qs9H03
pdb: 3qs9F02
pdb: 3qs7E04
pdb: 3qs7F04
pdb: 3qs7H03
pdb: 3qs9E04
pdb: 3qs9G04
pdb: 3qs9H04
pdb: 3qs9F03
pdb: 3qs9E05
pdb: 3qs9G05
pdb: 3qs9H05
pdb: 3qs9F04
pdb: 1rjbA01
pdb: 1rjbA02
pdb bound state: Unbound
  compound: ATP
  pdb: 3qs7E01
pdb bound state: Unbound
  compound: ATP
  pdb: 3qs7F01
pdb bound state: Unbound
  compound: ATP
  pdb: 3qs9E01
pdb bound state: Unbound
  compound: ATP
  pdb: 3qs9G01
pdb bound state: Unbound
  compound: ATP
  pdb: 3qs9H01
pdb bound state: Unbound
  compound: ATP
  pdb: 3qs7E02
pdb bound state: Unbound
  compound: ATP
  pdb: 3qs7F02
pdb bound state: Unbound
  compound: ATP
  pdb: 3qs7G01
pdb bound state: Unbound
  compound: ATP
  pdb: 3qs7H01
active site residues resources: Transformation by oncogenic mutants and ligand-dependent activation of FLT3 wild-type requires the tyrosine residues 589 and 591.
active site residues resources: P36888
references: Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots.
references: The structural basis for autoinhibition of FLT3 by the juxtamembrane domain.
references: Transformation by oncogenic mutants and ligand-dependent activation of FLT3 wild-type requires the tyrosine residues 589 and 591.
references: Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex.
comment: This enzyme belongs to platelet-derived growth factor (PDGF) receptor family, along with homologous enzymes, such as colony-stimulating factor-1 receptor (CSF-1-R, cFMS) (M00330 in EzCatDB) and tyrosine-protein kinase Kit (Kit) (M00323 in EzCatDB). The catalytic domain of this enzyme is homologous to that of vascular endothelial growth factor receptor (M00131 in EzCatDB).

Immunoglobulin-like
type: Cath
references: http://www.cathdb.info/version/latest/superfamily/2.60.40.10

Phosphorylase Kinase; domain 1
type: Cath
references: http://www.cathdb.info/version/latest/superfamily/3.30.200.20

Transferase(Phosphotransferase); domain 1
type: Cath
references: http://www.cathdb.info/version/latest/superfamily/1.10.510.10
catalytic domain: index.html

Mg
type: KeggCofactor
references: KEGG:C00305
compound type: divalent metal (Ca2+, Mg2+)
references: CHEBI:18420
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi

ATP
type: KeggSubstrate
references: KEGG:C00002
compound type: amine group
compound type: nucleotide
references: CHEBI:15422
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi

[protein]-L-tyrosine
type: KeggSubstrate
references: KEGG:C00585
compound type: aromatic ring (only carbon atom)
compound type: peptide/protein

ADP
type: KeggProduct
references: KEGG:C00008
compound type: amine group
compound type: nucleotide
references: CHEBI:16761
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi

[protein]-L-tyrosine phosphate
type: KeggProduct
references: KEGG:C01167
compound type: aromatic ring (only carbon atom)
compound type: peptide/protein
compound type: phosphate group/phosphate ion

1rjbA02
type: Pdb
references: 1rjb
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1rjb
catalytic residue: ASP 811;ARG 815
cofactor binding residue: ASN 816;ASP 829(Magnesium binding)

Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/10881197
journal: Nat Struct Biol
volume: 7
pages: 486-91
published year: 2000
authors:
  item: Savvides SN
  item: Boone T
  item: Andrew Karplus P

The structural basis for autoinhibition of FLT3 by the juxtamembrane domain.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/14759363
journal: Mol Cell
volume: 13
pages: 169-78
published year: 2004
authors:
  item: Griffith J
  item: Black J
  item: Faerman C
  item: Swenson L
  item: Wynn M
  item: Lu F
  item: Lippke J
  item: Saxena K
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: P36888

Transformation by oncogenic mutants and ligand-dependent activation of FLT3 wild-type requires the tyrosine residues 589 and 591.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/18628457
journal: Clin Cancer Res
volume: 14
pages: 4437-45
published year: 2008
authors:
  item: Vempati S
  item: Reindl C
  item: Wolf U
  item: Kern R
  item: Petropoulos K
  item: Naidu VM
  item: Buske C
  item: Hiddemann W
  item: Kohl TM
  item: Spiekermann K

Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/21389326
journal: Blood
volume: 118
pages: 60-8
published year: 2011
authors:
  item: Verstraete K
  item: Vandriessche G
  item: Januar M
  item: Elegheert J
  item: Shkumatov AV
  item: Desfosses A
  item: Van Craenenbroeck K
  item: Svergun DI
  item: Gutsche I
  item: Vergauwen B
  item: Savvides SN
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: P36888