Transferase(Phosphotransferase); domain 1
ATP:protein-tyrosine O-phosphotransferase (ambiguous)
Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots.
The structural basis for autoinhibition of FLT3 by the juxtamembrane domain.
Transformation by oncogenic mutants and ligand-dependent activation of FLT3 wild-type requires the tyrosine residues 589 and 591.
Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex.
This enzyme belongs to platelet-derived growth factor (PDGF) receptor family, along with homologous enzymes, such as colony-stimulating factor-1 receptor (CSF-1-R, cFMS) (M00330 in EzCatDB) and tyrosine-protein kinase Kit (Kit) (M00323 in EzCatDB). The catalytic domain of this enzyme is homologous to that of vascular endothelial growth factor receptor (M00131 in EzCatDB).