M00132
type: Enzyme
rlcp: p1162
cath: Immunoglobulin-like
cath: Phosphorylase Kinase; domain 1
cath: Transferase(Phosphotransferase); domain 1
ec: https://purl.uniprot.org/enzyme/2.7.10.1
uniprot: P04629
kegg enzyme: receptor protein-tyrosine kinase
kegg enzyme: AATK
kegg enzyme: AATYK
kegg enzyme: AATYK2
kegg enzyme: AATYK3
kegg enzyme: ACH
kegg enzyme: ALK
kegg enzyme: anaplastic lymphoma kinase
kegg enzyme: ARK
kegg enzyme: ATP:protein-tyrosine O-phosphotransferase (ambiguous)
kegg enzyme: AXL
kegg enzyme: Bek
kegg enzyme: Bfgfr
kegg enzyme: BRT
kegg enzyme: Bsk
kegg enzyme: C-FMS
kegg enzyme: CAK
kegg enzyme: CCK4
kegg enzyme: CD115
kegg enzyme: CD135
kegg enzyme: CDw135
kegg enzyme: Cek1
kegg enzyme: Cek10
kegg enzyme: Cek11
kegg enzyme: Cek2
kegg enzyme: Cek3
kegg enzyme: Cek5
kegg enzyme: Cek6
kegg enzyme: Cek7
kegg enzyme: CFD1
kegg enzyme: CKIT
kegg enzyme: CSF1R
kegg enzyme: DAlk
kegg enzyme: DDR1
kegg enzyme: DDR2
kegg enzyme: Dek
kegg enzyme: DKFZp434C1418
kegg enzyme: Drosophila Eph kinase
kegg enzyme: DRT
kegg enzyme: DTK
kegg enzyme: Ebk
kegg enzyme: ECK
kegg cofactor: Magnesium
kegg substrate: ATP
kegg substrate: [Protein]-L-tyrosine
kegg product: ADP
kegg product: [Protein]-L-tyrosine phosphate
pdb: 1he7A
pdb: 1wwaX
pdb: 1wwaY
pdb: 1wwwX
pdb: 1wwwY
references: The trk proto-oncogene encodes a receptor for nerve growth factor.
references: High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor.
references: A Trk nerve growth factor (NGF) receptor point mutation affecting interaction with phospholipase C-gamma 1 abolishes NGF-promoted peripherin induction but not neurite outgrowth.
references: Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses.
references: Structure and ligand recognition of the phosphotyrosine binding domain of Shc.
references: Trk receptors function as rapid retrograde signal carriers in the adult nervous system.
references: Cleavage of the TrkA neurotrophin receptor by multiple metalloproteases generates signalling-competent truncated forms.
references: The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation.
references: A novel point mutation affecting the tyrosine kinase domain of the TRKA gene in a family with congenital insensitivity to pain with anhidrosis.
references: Activity-dependent interaction of the intracellular domain of rat trkA with intermediate filament proteins, the beta-6 proteasomal subunit, Ras-GRF1, and the p162 subunit of eIF3.
references: Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor.
references: Direct binding of the signaling adapter protein Grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase, TrkA.
references: Identification of novel trkA variants with deletions in leucine-rich motifs of the extracellular domain.
references: Identification and structure of the nerve growth factor binding site on TrkA.
references: Analysis of trk A and p53 association.
references: Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor.
references: IRS-1 and IRS-2 are recruited by TrkA receptor and oncogenic TRK-T1.
references: SH2-B and APS are multimeric adapters that augment TrkA signaling.
references: A novel mutation within the extracellular domain of TrkA causes constitutive receptor activation.
references: Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules.
comment: The E.C. was transferred from 2.7.1.112 to 2.7.10.1. This receptor enzyme has N-terminal extracellular region, transmembrane region, and C-terminal cytoplasmic region. The extracellular region is composed of two Ig-like C2-type domains, whilst the cytoplasmic region contains protein kinase domain, which is homologous to other tyrosine protein kinase domains (M00129 in EzCatDB). The structure of the catalytic domain has not been obtained, though. This receptor belongs to the Insulin receptor superfamily. The PDB structures correspond to the second Ig-like C2-type domain.

Immunoglobulin-like
type: Cath
references: http://www.cathdb.info/version/latest/superfamily/2.60.40.10

Phosphorylase Kinase; domain 1
type: Cath
references: http://www.cathdb.info/version/latest/superfamily/3.30.200.20

Transferase(Phosphotransferase); domain 1
type: Cath
references: http://www.cathdb.info/version/latest/superfamily/1.10.510.10
catalytic domain: index.html

Magnesium
type: KeggCofactor
references: KEGG:C00305
compound type: divalent metal (Ca2+, Mg2+)
references: CHEBI:18420
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi

ATP
type: KeggSubstrate
references: KEGG:C00002
compound type: amine group
compound type: nucleotide
references: CHEBI:15422
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi

[Protein]-L-tyrosine
type: KeggSubstrate
references: KEGG:C00585
compound type: aromatic ring (only carbon atom)
compound type: peptide/protein

ADP
type: KeggProduct
references: KEGG:C00008
compound type: amine group
compound type: nucleotide
references: CHEBI:16761
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi

[Protein]-L-tyrosine phosphate
type: KeggProduct
references: KEGG:C01167
compound type: aromatic ring (only carbon atom)
compound type: peptide/protein
compound type: phosphate group/phosphate ion

The trk proto-oncogene encodes a receptor for nerve growth factor.
type: BibliographicResource
comment: FUNCTION
medline id: 91191557
references: http://www.ncbi.nlm.nih.gov/pubmed/1849459
journal: Cell
volume: 65
pages: 189-97
published year: 1991
authors:
  item: Klein R
  item: Jing SQ
  item: Nanduri V
  item: O'Rourke E
  item: Barbacid M
references: P04629

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor.
type: BibliographicResource
comment: FUNCTION
medline id: 91218846
references: http://www.ncbi.nlm.nih.gov/pubmed/1850821
journal: Nature
volume: 350
pages: 678-83
published year: 1991
authors:
  item: Hempstead BL
  item: Martin-Zanca D
  item: Kaplan DR
  item: Parada LF
  item: Chao MV
references: P04629

A Trk nerve growth factor (NGF) receptor point mutation affecting interaction with phospholipase C-gamma 1 abolishes NGF-promoted peripherin induction but not neurite outgrowth.
type: BibliographicResource
comment: MUTAGENESIS OF TYR-791
medline id: 94179299
references: http://www.ncbi.nlm.nih.gov/pubmed/7510697
journal: J Biol Chem
volume: 269
pages: 8901-10
published year: 1994
authors:
  item: Loeb DM
  item: Stephens RM
  item: Copeland T
  item: Kaplan DR
  item: Greene LA
references: P04629

Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses.
type: BibliographicResource
comment: MUTAGENESIS, AND PHOSPHORYLATION SITES
medline id: 94206546
references: http://www.ncbi.nlm.nih.gov/pubmed/8155326
journal: Neuron
volume: 12
pages: 691-705
published year: 1994
authors:
  item: Stephens RM
  item: Loeb DM
  item: Copeland TD
  item: Pawson T
  item: Greene LA
  item: Kaplan DR
references: P04629

Structure and ligand recognition of the phosphotyrosine binding domain of Shc.
type: BibliographicResource
comment: STRUCTURE BY NMR OF 489-500
medline id: 96097066
references: http://www.ncbi.nlm.nih.gov/pubmed/8524391
journal: Nature
volume: 378
pages: 584-92
published year: 1995
authors:
  item: Zhou MM
  item: Ravichandran KS
  item: Olejniczak EF
  item: Petros AM
  item: Meadows RP
  item: Sattler M
  item: Harlan JE
  item: Wade WS
  item: Burakoff SJ
  item: Fesik SW
references: P04629

Trk receptors function as rapid retrograde signal carriers in the adult nervous system.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9278536
journal: J Neurosci
volume: 17
pages: 7007-16
published year: 1997
authors:
  item: Bhattacharyya A
  item: Watson FL
  item: Bradlee TA
  item: Pomeroy SL
  item: Stiles CD
  item: Segal RA

Cleavage of the TrkA neurotrophin receptor by multiple metalloproteases generates signalling-competent truncated forms.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/10103137
journal: Eur J Neurosci
volume: 11
pages: 1421-30
published year: 1999
authors:
  item: Diaz-Rodriguez E
  item: Cabrera N
  item: Esparis-Ogando A
  item: Montero JC
  item: Pandiella A

The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/10092678
journal: J Biol Chem
volume: 274
pages: 9861-70
published year: 1999
authors:
  item: Meakin SO
  item: MacDonald JI
  item: Gryz EA
  item: Kubu CJ
  item: Verdi JM

A novel point mutation affecting the tyrosine kinase domain of the TRKA gene in a family with congenital insensitivity to pain with anhidrosis.
type: BibliographicResource
comment: VARIANT CIPA VAL-587
medline id: 99250414
references: http://www.ncbi.nlm.nih.gov/pubmed/10233776
journal: J Invest Dermatol
volume: 112
pages: 810-4
published year: 1999
authors:
  item: Yotsumoto S
  item: Setoyama M
  item: Hozumi H
  item: Mizoguchi S
  item: Fukumaru S
  item: Kobayashi K
  item: Saheki T
  item: Kanzaki T
references: P04629

Activity-dependent interaction of the intracellular domain of rat trkA with intermediate filament proteins, the beta-6 proteasomal subunit, Ras-GRF1, and the p162 subunit of eIF3.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/10691301
journal: J Mol Neurosci
volume: 13
pages: 141-58
published year: 1999
authors:
  item: MacDonald JI
  item: Verdi JM
  item: Meakin SO

Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/10490030
journal: Nature
volume: 401
pages: 184-8
published year: 1999
authors:
  item: Wiesmann C
  item: Ultsch MH
  item: Bass SH
  item: de Vos AM
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl

Direct binding of the signaling adapter protein Grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase, TrkA.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/10748052
journal: J Biol Chem
volume: 275
pages: 18225-33
published year: 2000
authors:
  item: MacDonald JI
  item: Gryz EA
  item: Kubu CJ
  item: Verdi JM
  item: Meakin SO

Identification of novel trkA variants with deletions in leucine-rich motifs of the extracellular domain.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/10808049
journal: J Neuroimmunol
volume: 107
pages: 42-9
published year: 2000
authors:
  item: Dubus P
  item: Parrens M
  item: El-Mokhtari Y
  item: Ferrer J
  item: Groppi A
  item: Merlio JP

Identification and structure of the nerve growth factor binding site on TrkA.
type: BibliographicResource
comment: X-ray crystallography
references: http://www.ncbi.nlm.nih.gov/pubmed/11263982
journal: Biochem Biophys Res Commun
volume: 282
pages: 131-41
published year: 2001
authors:
  item: Robertson AG
  item: Banfield MJ
  item: Allen SJ
  item: Dando JA
  item: Mason GG
  item: Tyler SJ
  item: Bennett GS
  item: Brain SD
  item: Clarke AR
  item: Naylor RL
  item: Wilcock GK
  item: Brady RL
  item: Dawbarn D
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl

Analysis of trk A and p53 association.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/11376656
journal: FEBS Lett
volume: 497
pages: 20-5
published year: 2001
authors:
  item: Browes C
  item: Rowe J
  item: Brown A
  item: Montano X

Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/11159935
journal: Hum Mol Genet
volume: 10
pages: 179-88
published year: 2001
authors:
  item: Mardy S
  item: Miura Y
  item: Endo F
  item: Matsuda I
  item: Indo Y

IRS-1 and IRS-2 are recruited by TrkA receptor and oncogenic TRK-T1.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/11147812
journal: J Cell Physiol
volume: 186
pages: 35-46
published year: 2001
authors:
  item: Miranda C
  item: Greco A
  item: Miele C
  item: Pierotti MA
  item: Van Obberghen E

SH2-B and APS are multimeric adapters that augment TrkA signaling.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/11238898
journal: Mol Cell Biol
volume: 21
pages: 1613-20
published year: 2001
authors:
  item: Qian X
  item: Ginty DD

A novel mutation within the extracellular domain of TrkA causes constitutive receptor activation.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/11313867
journal: Oncogene
volume: 20
pages: 1229-34
published year: 2001
authors:
  item: Arevalo JC
  item: Conde B
  item: Hempstead BI
  item: Chao MV
  item: Martin-Zanca D
  item: Perez P

Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/12446789
journal: Mol Cell Biol
volume: 22
pages: 8721-34
published year: 2002
authors:
  item: Nakamura T
  item: Komiya M
  item: Sone K
  item: Hirose E
  item: Gotoh N
  item: Morii H
  item: Ohta Y
  item: Mori N

EDDR1
type: KeggEnzyme

Eek
type: KeggEnzyme

EGFR
type: KeggEnzyme

Ehk2
type: KeggEnzyme

Ehk3
type: KeggEnzyme

Elk
type: KeggEnzyme

EPH
type: KeggEnzyme

EPHA1
type: KeggEnzyme

EPHA2
type: KeggEnzyme

EPHA6
type: KeggEnzyme

EPHA7
type: KeggEnzyme

EPHA8
type: KeggEnzyme

EPHB1
type: KeggEnzyme

EPHB2
type: KeggEnzyme

EPHB3
type: KeggEnzyme

EPHB4
type: KeggEnzyme

EphB5
type: KeggEnzyme

ephrin-B3 receptor tyrosine kinase
type: KeggEnzyme

EPHT
type: KeggEnzyme

EPHT2
type: KeggEnzyme

EPHT3
type: KeggEnzyme

EPHX
type: KeggEnzyme

ERBB
type: KeggEnzyme

ERBB1
type: KeggEnzyme

ERBB2
type: KeggEnzyme

ERBB3
type: KeggEnzyme

ERBB4
type: KeggEnzyme

ERK
type: KeggEnzyme

Eyk
type: KeggEnzyme

FGFR1
type: KeggEnzyme

FGFR2
type: KeggEnzyme

FGFR3
type: KeggEnzyme

FGFR4
type: KeggEnzyme

FLG
type: KeggEnzyme

FLK1
type: KeggEnzyme

FLK2
type: KeggEnzyme

FLT1
type: KeggEnzyme

FLT2
type: KeggEnzyme

FLT3
type: KeggEnzyme

FLT4
type: KeggEnzyme

FMS
type: KeggEnzyme

Fv2
type: KeggEnzyme

HBGFR
type: KeggEnzyme

HEK11
type: KeggEnzyme

HEK2
type: KeggEnzyme

HEK3
type: KeggEnzyme

HEK5
type: KeggEnzyme

HEK6
type: KeggEnzyme

HEP
type: KeggEnzyme

HER2
type: KeggEnzyme

HER3
type: KeggEnzyme

HER4
type: KeggEnzyme

HGFR
type: KeggEnzyme

HSCR1
type: KeggEnzyme

HTK
type: KeggEnzyme

IGF1R
type: KeggEnzyme

INSR
type: KeggEnzyme

INSRR
type: KeggEnzyme

insulin receptor protein-tyrosine kinase
type: KeggEnzyme

IR
type: KeggEnzyme

IRR
type: KeggEnzyme

JTK12
type: KeggEnzyme

JTK13
type: KeggEnzyme

JTK14
type: KeggEnzyme

JWS
type: KeggEnzyme

K-SAM
type: KeggEnzyme

KDR
type: KeggEnzyme

KGFR
type: KeggEnzyme

KIA0641
type: KeggEnzyme

KIAA1079
type: KeggEnzyme

KIAA1459
type: KeggEnzyme

Kil
type: KeggEnzyme

Kin15
type: KeggEnzyme

Kin16
type: KeggEnzyme

KIT
type: KeggEnzyme

KLG
type: KeggEnzyme

LTK
type: KeggEnzyme

MCF3
type: KeggEnzyme

Mdk1
type: KeggEnzyme

Mdk2
type: KeggEnzyme

Mdk5
type: KeggEnzyme

MEhk1
type: KeggEnzyme

MEN2A/B
type: KeggEnzyme

Mep
type: KeggEnzyme

MER
type: KeggEnzyme

MERTK
type: KeggEnzyme

MET
type: KeggEnzyme

Mlk1
type: KeggEnzyme

Mlk2
type: KeggEnzyme

Mrk
type: KeggEnzyme

MST1R
type: KeggEnzyme

MTC1
type: KeggEnzyme

MUSK
type: KeggEnzyme

Myk1
type: KeggEnzyme

N-SAM
type: KeggEnzyme

NEP
type: KeggEnzyme

NET
type: KeggEnzyme

Neu
type: KeggEnzyme

neurite outgrowth regulating kinase
type: KeggEnzyme

NGL
type: KeggEnzyme

NOK
type: KeggEnzyme

nork
type: KeggEnzyme

novel oncogene with kinase-domain
type: KeggEnzyme

Nsk2
type: KeggEnzyme

NTRK1
type: KeggEnzyme

NTRK2
type: KeggEnzyme

NTRK3
type: KeggEnzyme

NTRK4
type: KeggEnzyme

NTRKR1
type: KeggEnzyme

NTRKR2
type: KeggEnzyme

NTRKR3
type: KeggEnzyme

Nuk
type: KeggEnzyme

NYK
type: KeggEnzyme

PCL
type: KeggEnzyme

PDGFR
type: KeggEnzyme

PDGFRA
type: KeggEnzyme

PDGFRB
type: KeggEnzyme

PHB6
type: KeggEnzyme

protein-tyrosine kinase (ambiguous)
type: KeggEnzyme

protein tyrosine kinase (ambiguous)
type: KeggEnzyme

PTK
type: KeggEnzyme

PTK3
type: KeggEnzyme

PTK7
type: KeggEnzyme

receptor protein tyrosine kinase
type: KeggEnzyme

RET
type: KeggEnzyme

RON
type: KeggEnzyme

ROR1
type: KeggEnzyme

ROR2
type: KeggEnzyme

ROS1
type: KeggEnzyme

RSE
type: KeggEnzyme

RTK
type: KeggEnzyme

RYK
type: KeggEnzyme

SEA
type: KeggEnzyme

Sek2
type: KeggEnzyme

Sek3
type: KeggEnzyme

Sek4
type: KeggEnzyme

Sfr
type: KeggEnzyme

SKY
type: KeggEnzyme

STK
type: KeggEnzyme

STK1
type: KeggEnzyme

TEK
type: KeggEnzyme

TIE
type: KeggEnzyme

TIE1
type: KeggEnzyme

TIE2
type: KeggEnzyme

TIF
type: KeggEnzyme

TKT
type: KeggEnzyme

TRK
type: KeggEnzyme

TRKA
type: KeggEnzyme

TRKB
type: KeggEnzyme

TRKC
type: KeggEnzyme

TRKE
type: KeggEnzyme

TYK1
type: KeggEnzyme

TYRO10
type: KeggEnzyme

Tyro11
type: KeggEnzyme

TYRO3
type: KeggEnzyme

Tyro5
type: KeggEnzyme

Tyro6
type: KeggEnzyme

TYRO7
type: KeggEnzyme

UFO
type: KeggEnzyme

VEGFR1
type: KeggEnzyme

VEGFR2
type: KeggEnzyme

VEGFR3
type: KeggEnzyme

Vik
type: KeggEnzyme

YK1
type: KeggEnzyme

Yrk
type: KeggEnzyme