M00004
type: Enzyme
cath: Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2
cath: Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3
cath: Vanillyl-alcohol Oxidase; Chain A, domain 3
cath: Vanillyl-alcohol Oxidase; Chain A, domain 4
ec: https://purl.uniprot.org/enzyme/1.1.3.38
csa: 1vao
macie: M0103
uniprot: P56216
kegg enzyme: vanillyl-alcohol oxidase
kegg pathway: 2,4-Dichlorobenzoate degradation
kegg cofactor: FAD
kegg substrate: Vanillyl alcohol
kegg substrate: O2
kegg product: Vanillin
kegg product: H2O2
pdb: 1ahuA01
pdb: 1ahuB01
pdb: 1ahvA01
pdb: 1ahvB01
pdb: 1ahzA01
pdb: 1ahzB01
pdb: 1dznA01
pdb: 1dznB01
pdb: 1e0yA01
pdb: 1e0yB01
pdb: 1e8fA01
pdb: 1e8fB01
pdb: 1e8gA01
pdb: 1e8gB01
pdb: 1e8hA01
pdb: 1e8hB01
pdb: 1qltA01
pdb: 1qltB01
pdb: 1qluA01
pdb: 1qluB01
pdb: 1vaoA01
pdb: 1vaoB01
pdb: 1w1jA01
pdb: 1w1jB01
pdb: 1w1kA01
pdb: 1w1kB01
pdb: 1w1lA01
pdb: 1w1lB01
pdb: 1w1mA01
pdb: 1w1mB01
pdb: 2vaoA01
pdb: 2vaoB01
pdb: 1ahuA02
pdb: 1ahuB02
pdb: 1ahvA02
pdb: 1ahvB02
pdb: 1ahzA02
pdb: 1ahzB02
pdb: 1dznA02
pdb: 1dznB02
pdb: 1e0yA02
pdb: 1e0yB02
pdb: 1e8fA02
pdb: 1e8fB02
pdb: 1e8gA02
pdb: 1e8gB02
pdb: 1e8hA02
pdb: 1e8hB02
pdb: 1qltA02
pdb: 1qltB02
pdb: 1qluA02
pdb: 1qluB02
pdb: 1vaoA02
pdb: 1vaoB02
pdb: 1w1jA02
pdb: 1w1jB02
pdb: 1w1kA02
pdb: 1w1kB02
pdb: 1w1lA02
pdb: 1w1lB02
pdb: 1w1mA02
pdb: 1w1mB02
pdb: 2vaoA02
pdb: 2vaoB02

Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2
type: Cath
references: http://www.cathdb.info/version/latest/superfamily/3.30.43.10
catalytic domain: index.html

Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3
type: Cath
references: http://www.cathdb.info/version/latest/superfamily/3.30.465.20
catalytic domain: index.html

Vanillyl-alcohol Oxidase; Chain A, domain 3
type: Cath
references: http://www.cathdb.info/version/latest/superfamily/3.40.462.10
catalytic domain: index.html

Vanillyl-alcohol Oxidase; Chain A, domain 4
type: Cath
references: http://www.cathdb.info/version/latest/superfamily/1.10.45.10

2,4-Dichlorobenzoate degradation
type: KeggPathway
references: KEGG:MAP00623

FAD
type: KeggCofactor
references: KEGG:C00016
compound type: amide group
compound type: amine group
compound type: aromatic ring (only carbon atom)
compound type: aromatic ring (with nitrogen atoms)
compound type: carbohydrate
compound type: nucleotide
references: CHEBI:16238
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi

Vanillyl alcohol
type: KeggSubstrate
references: KEGG:C06317
compound type: aromatic ring (only carbon atom)
compound type: carbohydrate
references: CHEBI:18353
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi

O2
type: KeggSubstrate
references: KEGG:C00007
compound type: others
references: CHEBI:15379
references: CHEBI:26689
references: CHEBI:27140
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi

Vanillin
type: KeggProduct
references: KEGG:C00755
compound type: aromatic ring (only carbon atom)
compound type: carbohydrate
references: CHEBI:18346
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi

H2O2
type: KeggProduct
references: KEGG:C00027
compound type: others
references: CHEBI:16240
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi

1ahuA01
type: Pdb
references: 1ahu
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ahu
catalytic residue: TYR 108

1ahuB01
type: Pdb
references: 1ahu
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ahu
catalytic residue: TYR 108

1ahvA01
type: Pdb
references: 1ahv
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ahv
catalytic residue: TYR 108

1ahvB01
type: Pdb
references: 1ahv
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ahv
catalytic residue: TYR 108

1ahzA01
type: Pdb
references: 1ahz
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ahz
catalytic residue: TYR 108

1ahzB01
type: Pdb
references: 1ahz
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ahz
catalytic residue: TYR 108

1dznA01
type: Pdb
references: 1dzn
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dzn
catalytic residue: TYR 108

1dznB01
type: Pdb
references: 1dzn
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dzn
catalytic residue: TYR 108

1e0yA01
type: Pdb
references: 1e0y
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e0y
catalytic residue: TYR 108

1e0yB01
type: Pdb
references: 1e0y
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e0y
catalytic residue: TYR 108

1e8fA01
type: Pdb
references: 1e8f
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e8f
catalytic residue: TYR 108
comment: mutant H61T

1e8fB01
type: Pdb
references: 1e8f
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e8f
catalytic residue: TYR 108
comment: mutant H61T

1e8gA01
type: Pdb
references: 1e8g
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e8g
catalytic residue: TYR 108
comment: mutant H61T

1e8gB01
type: Pdb
references: 1e8g
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e8g
catalytic residue: TYR 108
comment: mutant H61T

1e8hA01
type: Pdb
references: 1e8h
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e8h
catalytic residue: TYR 108
comment: mutant H61T

1e8hB01
type: Pdb
references: 1e8h
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e8h
catalytic residue: TYR 108
comment: mutant H61T

1qltA01
type: Pdb
references: 1qlt
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1qlt
catalytic residue: TYR 108

1qltB01
type: Pdb
references: 1qlt
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1qlt
catalytic residue: TYR 108

1qluA01
type: Pdb
references: 1qlu
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1qlu
catalytic residue: TYR 108

1qluB01
type: Pdb
references: 1qlu
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1qlu
catalytic residue: TYR 108

1vaoA01
type: Pdb
references: 1vao
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1vao
catalytic residue: TYR 108

1vaoB01
type: Pdb
references: 1vao
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1vao
catalytic residue: TYR 108

1w1jA01
type: Pdb
references: 1w1j
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1j
catalytic residue: TYR 108

1w1jB01
type: Pdb
references: 1w1j
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1j
catalytic residue: TYR 108

1w1kA01
type: Pdb
references: 1w1k
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1k
catalytic residue: TYR 108

1w1kB01
type: Pdb
references: 1w1k
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1k
catalytic residue: TYR 108

1w1lA01
type: Pdb
references: 1w1l
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1l
catalytic residue: TYR 108

1w1lB01
type: Pdb
references: 1w1l
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1l
catalytic residue: TYR 108

1w1mA01
type: Pdb
references: 1w1m
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1m
catalytic residue: TYR 108

1w1mB01
type: Pdb
references: 1w1m
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1m
catalytic residue: TYR 108

2vaoA01
type: Pdb
references: 2vao
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2vao
catalytic residue: TYR 108

2vaoB01
type: Pdb
references: 2vao
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2vao
catalytic residue: TYR 108

1ahuA02
type: Pdb
references: 1ahu
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ahu
catalytic residue: ASP 170

1ahuB02
type: Pdb
references: 1ahu
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ahu
catalytic residue: ASP 170

1ahvA02
type: Pdb
references: 1ahv
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ahv
catalytic residue: ASP 170

1ahvB02
type: Pdb
references: 1ahv
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ahv
catalytic residue: ASP 170

1ahzA02
type: Pdb
references: 1ahz
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ahz
catalytic residue: ASP 170

1ahzB02
type: Pdb
references: 1ahz
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ahz
catalytic residue: ASP 170

1dznA02
type: Pdb
references: 1dzn
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dzn
comment: mutant D170S

1dznB02
type: Pdb
references: 1dzn
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dzn
comment: mutant D170S

1e0yA02
type: Pdb
references: 1e0y
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e0y
comment: mutant D170S

1e0yB02
type: Pdb
references: 1e0y
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e0y
comment: mutant D170S

1e8fA02
type: Pdb
references: 1e8f
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e8f
catalytic residue: ASP 170

1e8fB02
type: Pdb
references: 1e8f
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e8f
catalytic residue: ASP 170

1e8gA02
type: Pdb
references: 1e8g
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e8g
catalytic residue: ASP 170

1e8gB02
type: Pdb
references: 1e8g
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e8g
catalytic residue: ASP 170

1e8hA02
type: Pdb
references: 1e8h
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e8h
catalytic residue: ASP 170

1e8hB02
type: Pdb
references: 1e8h
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e8h
catalytic residue: ASP 170

1qltA02
type: Pdb
references: 1qlt
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1qlt
catalytic residue: ASP 170

1qltB02
type: Pdb
references: 1qlt
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1qlt
catalytic residue: ASP 170

1qluA02
type: Pdb
references: 1qlu
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1qlu
catalytic residue: ASP 170

1qluB02
type: Pdb
references: 1qlu
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1qlu
catalytic residue: ASP 170

1vaoA02
type: Pdb
references: 1vao
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1vao
catalytic residue: ASP 170

1vaoB02
type: Pdb
references: 1vao
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1vao
catalytic residue: ASP 170

1w1jA02
type: Pdb
references: 1w1j
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1j
catalytic residue: ASP 170

1w1jB02
type: Pdb
references: 1w1j
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1j
catalytic residue: ASP 170

1w1kA02
type: Pdb
references: 1w1k
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1k
catalytic residue: ASP 170
comment: mutant I238T

1w1kB02
type: Pdb
references: 1w1k
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1k
catalytic residue: ASP 170
comment: mutant I238T

1w1lA02
type: Pdb
references: 1w1l
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1l
catalytic residue: ASP 170

1w1lB02
type: Pdb
references: 1w1l
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1l
catalytic residue: ASP 170

1w1mA02
type: Pdb
references: 1w1m
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1m
catalytic residue: ASP 170

1w1mB02
type: Pdb
references: 1w1m
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1m
catalytic residue: ASP 170

2vaoA02
type: Pdb
references: 2vao
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2vao
catalytic residue: ASP 170

2vaoB02
type: Pdb
references: 2vao
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2vao
catalytic residue: ASP 170

1ahuA03
type: Pdb
references: 1ahu
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ahu
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)

1ahuB03
type: Pdb
references: 1ahu
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ahu
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)

1ahvA03
type: Pdb
references: 1ahv
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ahv
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)

1ahvB03
type: Pdb
references: 1ahv
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ahv
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)

1ahzA03
type: Pdb
references: 1ahz
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ahz
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)

1ahzB03
type: Pdb
references: 1ahz
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1ahz
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)

1dznA03
type: Pdb
references: 1dzn
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dzn
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)

1dznB03
type: Pdb
references: 1dzn
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dzn
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)

1e0yA03
type: Pdb
references: 1e0y
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e0y
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)
comment: mutant T457E

1e0yB03
type: Pdb
references: 1e0y
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e0y
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)
comment: mutant T457E

1e8fA03
type: Pdb
references: 1e8f
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e8f
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)

1e8fB03
type: Pdb
references: 1e8f
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e8f
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)

1e8gA03
type: Pdb
references: 1e8g
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e8g
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)

1e8gB03
type: Pdb
references: 1e8g
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e8g
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)

1e8hA03
type: Pdb
references: 1e8h
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e8h
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)

1e8hB03
type: Pdb
references: 1e8h
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e8h
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)

1qltA03
type: Pdb
references: 1qlt
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1qlt
catalytic residue: TYR 503;ARG 504
comment: mutant H422A

1qltB03
type: Pdb
references: 1qlt
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1qlt
catalytic residue: TYR 503;ARG 504
comment: mutant H422A

1qluA03
type: Pdb
references: 1qlu
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1qlu
catalytic residue: TYR 503;ARG 504
comment: mutant H422A

1qluB03
type: Pdb
references: 1qlu
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1qlu
catalytic residue: TYR 503;ARG 504
comment: mutant H422A

1vaoA03
type: Pdb
references: 1vao
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1vao
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)

1vaoB03
type: Pdb
references: 1vao
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1vao
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)

1w1jA03
type: Pdb
references: 1w1j
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1j
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)
comment: mutant T505S

1w1jB03
type: Pdb
references: 1w1j
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1j
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)
comment: mutant T505S

1w1kA03
type: Pdb
references: 1w1k
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1k
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)

1w1kB03
type: Pdb
references: 1w1k
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1k
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)

1w1lA03
type: Pdb
references: 1w1l
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1l
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)
comment: mutant F454Y

1w1lB03
type: Pdb
references: 1w1l
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1l
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)
comment: mutant F454Y

1w1mA03
type: Pdb
references: 1w1m
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1m
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)
comment: mutant E502G

1w1mB03
type: Pdb
references: 1w1m
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1w1m
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)
comment: mutant E502G

2vaoA03
type: Pdb
references: 2vao
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2vao
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)

2vaoB03
type: Pdb
references: 2vao
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:2vao
catalytic residue: TYR 503;ARG 504
cofactor binding residue: HIS 422(FAD binding)

Analogue
compound: Vanillyl alcohol
pdb: 1ahuA03
ligand het code: FAA

Analogue
compound: Vanillyl alcohol
pdb: 1ahuB03
ligand het code: FAA

Analogue
compound: Vanillyl alcohol
pdb: 1ahvA03
ligand het code: NCR

Analogue
compound: Vanillyl alcohol
pdb: 1ahvB03
ligand het code: NCR

Analogue
compound: Vanillyl alcohol
pdb: 1ahzA03
ligand het code: EPT

Analogue
compound: Vanillyl alcohol
pdb: 1e0yB03
ligand het code: FCR

Analogue
compound: Vanillyl alcohol
pdb: 1e8gA03
ligand het code: FCR

Analogue
compound: Vanillyl alcohol
pdb: 1e8gB03
ligand het code: FCR

Analogue
compound: Vanillyl alcohol
pdb: 1qluA03
ligand het code: EUG

Analogue
compound: Vanillyl alcohol
pdb: 1qluB03
ligand het code: EUG

Analogue
compound: FAD
pdb: 1ahuA01
ligand het code: FAA

Analogue
compound: FAD
pdb: 1ahuB01
ligand het code: FAA

Analogue
compound: FAD
pdb: 1e8hA01
ligand het code: ADP

Analogue
compound: FAD
pdb: 1e8hB01
ligand het code: ADP

Analogue
compound: FAD
pdb: 1w1lA01
ligand het code: EUG-FAD

Analogue
compound: FAD
pdb: 1w1lB01
ligand het code: EUG-FAD

Analogue
compound: Vanillin
pdb: 1dznA03
ligand het code: EUG

Analogue
compound: Vanillin
pdb: 1dznB03
ligand het code: EUG

Analogue
compound: Vanillin
pdb: 1qluA03
ligand het code: EUG

Analogue
compound: Vanillin
pdb: 1qluB03
ligand het code: EUG

Analogue
compound: Vanillin
pdb: 1w1jA03
ligand het code: EUG

Analogue
compound: Vanillin
pdb: 1w1jB03
ligand het code: EUG

Analogue
compound: Vanillin
pdb: 1w1kA03
ligand het code: EUG

Analogue
compound: Vanillin
pdb: 1w1kB03
ligand het code: EUG

Analogue
compound: Vanillin
pdb: 1w1lA03
ligand het code: EUG

Analogue
compound: Vanillin
pdb: 1w1lB03
ligand het code: EUG

Analogue
compound: Vanillin
pdb: 1w1mA03
ligand het code: EUG

Analogue
compound: Vanillin
pdb: 1w1mB03
ligand het code: EUG

Analogue
compound: Vanillin
pdb: 2vaoA03
ligand het code: EUG

Analogue
compound: Vanillin
pdb: 2vaoB03
ligand het code: EUG

ReferenceForCatalyticMechanism
reference index: 2
reference section: p.276-277

ReferenceForCatalyticMechanism
reference index: 4
reference section: Equation 4, Scheme 1, p.18115-18116

ReferenceForCatalyticMechanism
reference index: 6
reference section: Fig.10, p.915-917

ReferenceForCatalyticMechanism
reference index: 7
reference section: Scheme 1, p.35518-35520

ReferenceForCatalyticMechanism
reference index: 8
reference section: Scheme 1, Fig.3, p.109

ReferenceForCatalyticMechanism
reference index: 10
reference section: Fig.1, Fig.8, p.14806-14807

ReferenceForCatalyticMechanism
reference index: 11
reference section: Scheme 1, Fig.5, p.9454-9456

ReferenceForCatalyticMechanism
reference index: 13
reference section: Fig.1

ReferenceForCatalyticMechanism
reference index: 16
reference section: Fig.2, p.182-186

ReferenceForCatalyticMechanism
reference index: 17
reference section: Fig.1, p.33498-33499

Purification and characterization of vanillyl-alcohol oxidase from Penicillium simplicissimum. A novel aromatic alcohol oxidase containing covalently bound FAD.
type: BibliographicResource
comment: CHARACTERIZATION
medline id: 93011092
references: http://www.ncbi.nlm.nih.gov/pubmed/1396672
journal: Eur J Biochem
volume: 208
pages: 651-7
published year: 1992
authors:
  item: de Jong E
  item: van Berkel WJ
  item: van der Zwan RP
  item: de Bont JA
references: P56216

Substrate specificity of flavin-dependent vanillyl-alcohol oxidase from Penicillium simplicissimum. Evidence for the production of 4-hydroxycinnamyl alcohols from 4-allylphenols.
type: BibliographicResource
comment: SUBSTRATE SPECIFICITY
medline id: 96096749
references: http://www.ncbi.nlm.nih.gov/pubmed/8529652
journal: Eur J Biochem
volume: 234
pages: 271-7
published year: 1995
authors:
  item: Fraaije MW
  item: Veeger C
  item: van Berkel WJ
references: P56216

Mercuration of vanillyl-alcohol oxidase from Penicillium simplicissimum generates inactive dimers.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9013853
journal: FEBS Lett
volume: 402
pages: 33-5
published year: 1997
authors:
  item: Fraaije MW
  item: Mattevi A
  item: van Berkel WJ

Catalytic mechanism of the oxidative demethylation of 4-(methoxymethyl)phenol by vanillyl-alcohol oxidase. Evidence for formation of a p-quinone methide intermediate.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9218444
journal: J Biol Chem
volume: 272
pages: 18111-6
published year: 1997
authors:
  item: Fraaije MW
  item: van Berkel WJ

Crystallization and preliminary X-ray analysis of the flavoenzyme vanillyl-alcohol oxidase from Penicillium simplicissimum.
type: BibliographicResource
comment: X-RAY CRYSTALLOGRAPHY (2.5 AND 3.2 ANGSTROMS)
medline id: 97285922
references: http://www.ncbi.nlm.nih.gov/pubmed/9141139
journal: Proteins
volume: 27
pages: 601-3
published year: 1997
authors:
  item: Mattevi A
  item: Fraaije MW
  item: Coda A
  item: van Berkel WJ
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: P56216

Crystal structures and inhibitor binding in the octameric flavoenzyme vanillyl-alcohol oxidase: the shape of the active-site cavity controls substrate specificity.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9261083
journal: Structure
volume: 5
pages: 907-20
published year: 1997
authors:
  item: Mattevi A
  item: Fraaije MW
  item: Mozzarelli A
  item: Olivi L
  item: Coda A
  item: van Berkel WJ

Covalent flavinylation is essential for efficient redox catalysis in vanillyl-alcohol oxidase.
type: BibliographicResource
comment: X-RAY CRYSTALLOGRAPHY OF MUTANTS (2.2 ANGSTROMS)
medline id: 20054426
references: http://www.ncbi.nlm.nih.gov/pubmed/10585424
journal: J Biol Chem
volume: 274
pages: 35514-20
published year: 1999
authors:
  item: Fraaije MW
  item: van den Heuvel RH
  item: van Berkel WJ
  item: Mattevi A
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: P56216

Direction of the reactivity of vanillyl-alcohol oxidase with 4-alkylphenols.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/10996306
journal: FEBS Lett
volume: 481
pages: 109-12
published year: 2000
authors:
  item: van den Heuvel RH
  item: Fraaije MW
  item: van Berkel WJ

Structural analysis of flavinylation in vanillyl-alcohol oxidase.
type: BibliographicResource
comment: X-RAY CRYSTALLOGRAPHY OF MUTANTS (2.1 ANGSTROMS)
medline id: 20556311
references: http://www.ncbi.nlm.nih.gov/pubmed/10984479
journal: J Biol Chem
volume: 275
pages: 38654-8
published year: 2000
authors:
  item: Fraaije MW
  item: van Den Heuvel RH
  item: van Berkel WJ
  item: Mattevi A
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: P56216

Asp-170 is crucial for the redox properties of vanillyl-alcohol oxidase.
type: BibliographicResource
comment: X-RAY CRYSTALLOGRAPHY OF D170S MUTANT (2.8 ANGSTROMS)
medline id: 20270176
references: http://www.ncbi.nlm.nih.gov/pubmed/10809721
journal: J Biol Chem
volume: 275
pages: 14799-808
published year: 2000
authors:
  item: van den Heuvel RH
  item: Fraaije MW
  item: Mattevi A
  item: van Berkel WJ
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: P56216

Inversion of stereospecificity of vanillyl-alcohol oxidase.
type: BibliographicResource
comment: X-RAY CRYSTALLOGRAPHY OF D170S/T457E MUTANT (2.75 ANGSTROMS)
medline id: 20402555
references: http://www.ncbi.nlm.nih.gov/pubmed/10920192
journal: Proc Natl Acad Sci U S A
volume: 97
pages: 9455-60
published year: 2000
authors:
  item: van Den Heuvel RH
  item: Fraaije MW
  item: Ferrer M
  item: Mattevi A
  item: van Berkel WJ
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: P56216

Detection of intact megaDalton protein assemblies of vanillyl-alcohol oxidase by mass spectrometry.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/10752605
journal: Protein Sci
volume: 9
pages: 435-9
published year: 2000
authors:
  item: van Berkel WJ
  item: van den Heuvel RH
  item: Versluis C
  item: Heck AJ

Flavoenzymes: diverse catalysts with recurrent features.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/10694883
journal: Trends Biochem Sci
volume: 25
pages: 126-32
published year: 2000
authors:
  item: Fraaije MW
  item: Mattevi A

Tuning of the product spectrum of vanillyl-alcohol oxidase by medium engineering.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/11513884
journal: FEBS Lett
volume: 503
pages: 213-6
published year: 2001
authors:
  item: van den Heuvel RH
  item: Partridge J
  item: Laane C
  item: Halling PJ
  item: van Berkel WJ

Cofactor-dependent assembly of the flavoenzyme vanillyl-alcohol oxidase.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/12107187
journal: J Biol Chem
volume: 277
pages: 36425-32
published year: 2002
authors:
  item: Tahallah N
  item: Van Den Heuvel RH
  item: Van Den Berg WA
  item: Maier CS
  item: Van Berkel WJ
  item: Heck AJ

Redox properties of vanillyl-alcohol oxidase.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/12078493
journal: Methods Enzymol
volume: 353
pages: 177-86
published year: 2002
authors:
  item: van den Heuvel RH
  item: Fraaije MW
  item: van Berkel WJ

Laboratory-evolved vanillyl-alcohol oxidase produces natural vanillin.
type: BibliographicResource
comment: X-ray crystallography
references: http://www.ncbi.nlm.nih.gov/pubmed/15169773
journal: J Biol Chem
volume: 279
pages: 33492-500
published year: 2004
authors:
  item: van den Heuvel RH
  item: van den Berg WA
  item: Rovida S
  item: van Berkel WJ
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl

4-hydroxy-2-methoxybenzyl alcohol oxidase
type: KeggEnzyme