D00169
type: Enzyme
rlcp: p970
cath: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
cath: TIM Barrel
ec: https://purl.uniprot.org/enzyme/3.2.1.8
uniprot: P26514
uniprot: Q7SI98
kegg enzyme: endo-1,4-beta-xylanase
kegg substrate: Xylan
kegg substrate: H2O
kegg product: Xylan
pdb: 1xyfA01
pdb: 1xyfB01
pdb: 1isvA01
pdb: 1isvB01
pdb: 1iswA01
pdb: 1iswB01
pdb: 1isxA01
pdb: 1isxB01
pdb: 1isyA01
pdb: 1isyB01
pdb: 1iszA01
pdb: 1iszB01
pdb: 1it0A01
pdb: 1it0B01
pdb: 1knlA
pdb: 1knmA
pdb: 1mc9A
pdb: 1xyfA02
pdb: 1xyfB02
pdb: 1isvA02
pdb: 1isvB02
pdb: 1iswA02
pdb: 1iswB02
pdb: 1isxA02
pdb: 1isxB02
pdb: 1isyA02
pdb: 1isyB02
pdb: 1iszA02
pdb: 1iszB02
pdb: 1it0A02
pdb: 1it0B02
pdb: 1e0vA
pdb: 1e0wA
pdb: 1e0xA
pdb: 1e0xB
pdb: 1od8A
active site residues resources: P26514
active site residues resources: 1xyf
references: Multiplicity of beta-1,4-xylanase in microorganisms: functions and applications.
references: Structure of rice-straw arabinoglucuronoxylan and specificity of Streptomyces xylanase toward the xylan.
references: Structural and functional relationships in two families of beta-1,4-glycanases.
references: Domains in microbial beta-1, 4-glycanases: sequence conservation, function, and enzyme families.
references: Mode of action of three endo-beta-1,4-xylanases of Streptomyces lividans.
references: Characterization and N-terminal amino acid sequences of beta-(1-4)endoxylanases from Streptomyces roseiscleroticus: purification incorporating a bioprocessing agent.
references: Identification of two acidic residues involved in the catalysis of xylanase A from Streptomyces lividans.
references: Substrate specificity of Streptomyces beta-xylanase toward glucoxylan.
references: The xylan-degrading enzyme system.
references: Increase in catalytic activity and thermostability of the xylanase A of Streptomyces lividans 1326 by site-specific mutagenesis.
references: Alteration of the cleavage mode and of the transglycosylation reactions of the xylanase A of Streptomyces lividans 1326 by site-directed mutagenesis of the Asn173 residue.
references: Crystal structure, at 2.6-A resolution, of the Streptomyces lividans xylanase A, a member of the F family of beta-1,4-D-glycanases.
references: http://ezcatdb.cbrc.jp/EzCatDB/reference/D00169#13
references: Characterization of two important histidine residues in the active site of xylanase A from Streptomyces lividans, a family 10 glycanase.
references: Xylanolytic enzymes from fungi and bacteria.
references: http://ezcatdb.cbrc.jp/EzCatDB/reference/D00169#16
references: Calcium protects a mesophilic xylanase from proteinase inactivation and thermal unfolding.
references: Endo-beta-1,4-xylanase families: differences in catalytic properties.
references: Asparagine-127 of xylanase A from Streptomyces lividans, a key residue in glycosyl hydrolases of superfamily 4/7: kinetic evidence for its involvement in stabilization of the catalytic intermediate.
references: Site-directed mutagenesis study of a conserved residue in family 10 glycanases: histidine 86 of xylanase A from Streptomyces lividans.
references: http://ezcatdb.cbrc.jp/EzCatDB/reference/D00169#21
references: Significant enhancement in the binding of p-nitrophenyl-beta-D-xylobioside by the E128H mutant F/10 xylanase from Streptomyces olivaceoviridis E-86.
references: Module-intron correlation and intron sliding in family F/10 xylanase genes.
references: Characterization of active-site aromatic residues in xylanase A from Streptomyces lividans.
references: Crystal structure of Streptomyces olivaceoviridis E-86 beta-xylanase containing xylan-binding domain.
references: http://ezcatdb.cbrc.jp/EzCatDB/reference/D00169#26
references: Crystal structures of the sugar complexes of Streptomyces olivaceoviridis E-86 xylanase: sugar binding structure of the family 13 carbohydrate binding module.
references: High-resolution crystal structures of the lectin-like xylan binding domain from Streptomyces lividans xylanase 10A with bound substrates reveal a novel mode of xylan binding.
references: A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer.
references: Structure and function of a family 10 beta-xylanase chimera of Streptomyces olivaceoviridis E-86 FXYN and Cellulomonas fimi Cex.
comment: This family belongs to the glycosidase family-10, which has a retaining mechanism (equatorial to equatorial conformation), and also a family of 4/7 superfamily, which has got catalytic residues at the C-terminal ends of beta-4 and beta-7 on the (alpha/beta)8 barrel fold. According to the literature [22], Glu236 and Glu128 (of 1ece) act as a nucleophile and acid-base, respectively. The catalysis proceeds through a dissociative-type (or SN1-like) mechanism, with a formation of oxocarbonium ion in the transition state, during the glycosylation of the active site. During the glycosylation, Glu236 approaches the C1 atom of xylan substrate, whilst Glu128 protonates the leaving sugar group. At the second stage, or during the deglycosylation, a water molecule can be activated by a general base, Glu128. This deglycosylation also goes through the dissociative-type reaction with an oxocarbonium ion in the transition state, in which water replaced the xylan leaving group in the first step. According to the paper [19], the conserved residue at active site, Asn127, may stabilize the intermediate or transition state. Meanwhile, the paper [20] mentioned that His86 might modulate the acid-base catalyst (Glu128), by maintaining the elevated pKa of the catalytic residue. Moreover, comparing the structural data with that of the other family-10 enzyme, xylanase (E.C. 3.2.1.8) (D00479 in EzCatDB), His207-Asp238 dyad seems to stabilize the leaving nucleophile, Glu236, during the deglycosylation.

Trefoil (Acidic Fibroblast Growth Factor, subunit A)
type: Cath
references: http://www.cathdb.info/version/latest/superfamily/2.80.10.50

TIM Barrel
type: Cath
references: http://www.cathdb.info/version/latest/superfamily/3.20.20.80
catalytic domain: index.html

Xylan
type: KeggSubstrate
references: KEGG:C00707
compound type: polysaccharide
type: KeggProduct

H2O
type: KeggSubstrate
references: KEGG:C00001
compound type: H2O
references: CHEBI:15377
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi

1xyfA02
type: Pdb
references: 1xyf
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1xyf
catalytic residue: GLU 128;HIS 207;GLU 236;ASP 238

1xyfB02
type: Pdb
references: 1xyf
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1xyf
catalytic residue: GLU 628;HIS 707;GLU 736;ASP 738

1isvA02
type: Pdb
references: 1isv
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1isv
catalytic residue: GLU 128;HIS 207;GLU 236;ASP 238

1isvB02
type: Pdb
references: 1isv
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1isv
catalytic residue: GLU 628;HIS 707;GLU 736;ASP 738

1iswA02
type: Pdb
references: 1isw
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1isw
catalytic residue: GLU 128;HIS 207;GLU 236;ASP 238

1iswB02
type: Pdb
references: 1isw
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1isw
catalytic residue: GLU 628;HIS 707;GLU 736;ASP 738

1isxA02
type: Pdb
references: 1isx
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1isx
catalytic residue: GLU 128;HIS 207;GLU 236;ASP 238

1isxB02
type: Pdb
references: 1isx
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1isx
catalytic residue: GLU 628;HIS 707;GLU 736;ASP 738

1isyA02
type: Pdb
references: 1isy
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1isy
catalytic residue: GLU 128;HIS 207;GLU 236;ASP 238

1isyB02
type: Pdb
references: 1isy
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1isy
catalytic residue: GLU 628;HIS 707;GLU 736;ASP 738

1iszA02
type: Pdb
references: 1isz
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1isz
catalytic residue: GLU 128;HIS 207;GLU 236;ASP 238

1iszB02
type: Pdb
references: 1isz
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1isz
catalytic residue: GLU 628;HIS 707;GLU 736;ASP 738

1it0A02
type: Pdb
references: 1it0
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1it0
catalytic residue: GLU 128;HIS 207;GLU 236;ASP 238

1it0B02
type: Pdb
references: 1it0
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1it0
catalytic residue: GLU 628;HIS 707;GLU 736;ASP 738

1e0vA
type: Pdb
references: 1e0v
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e0v
catalytic residue: GLU 128;HIS 207;GLU 236;ASP 238

1e0wA
type: Pdb
references: 1e0w
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e0w
catalytic residue: GLU 128;HIS 207;GLU 236;ASP 238

1e0xA
type: Pdb
references: 1e0x
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e0x
catalytic residue: GLU 128;HIS 207;GLU 236;ASP 238

1e0xB
type: Pdb
references: 1e0x
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1e0x
catalytic residue: GLU 128;HIS 207;GLU 236;ASP 238

1od8A
type: Pdb
references: 1od8
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1od8
catalytic residue: GLU 128;HIS 207;GLU 236;ASP 238

Multiplicity of beta-1,4-xylanase in microorganisms: functions and applications.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/3141761
journal: Microbiol Rev
volume: 52
pages: 305-17
published year: 1988
authors:
  item: Wong KK
  item: Tan LU
  item: Saddler JN

Structure of rice-straw arabinoglucuronoxylan and specificity of Streptomyces xylanase toward the xylan.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/1368510
journal: Agric Biol Chem
volume: 54
pages: 449-57
published year: 1990
authors:
  item: Yoshida S
  item: Kusakabe I
  item: Matsuo N
  item: Shimizu K
  item: Yasui T
  item: Murakami K

Structural and functional relationships in two families of beta-1,4-glycanases.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/1761039
journal: Eur J Biochem
volume: 202
pages: 367-77
published year: 1991
authors:
  item: Gilkes NR
  item: Claeyssens M
  item: Aebersold R
  item: Henrissat B
  item: Meinke A
  item: Morrison HD
  item: Kilburn DG
  item: Warren RA
  item: Miller RC Jr

Domains in microbial beta-1, 4-glycanases: sequence conservation, function, and enzyme families.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/1886523
journal: Microbiol Rev
volume: 55
pages: 303-15
published year: 1991
authors:
  item: Gilkes NR
  item: Henrissat B
  item: Kilburn DG
  item: Miller RC Jr
  item: Warren RA

Mode of action of three endo-beta-1,4-xylanases of Streptomyces lividans.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/8457588
journal: Biochim Biophys Acta
volume: 1162
pages: 246-54
published year: 1993
authors:
  item: Biely P
  item: Kluepfel D
  item: Morosoli R
  item: Shareck F

Characterization and N-terminal amino acid sequences of beta-(1-4)endoxylanases from Streptomyces roseiscleroticus: purification incorporating a bioprocessing agent.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/8471845
journal: Protein Expr Purif
volume: 4
pages: 120-9
published year: 1993
authors:
  item: Grabski AC
  item: Forrester IT
  item: Patel R
  item: Jeffries TW

Identification of two acidic residues involved in the catalysis of xylanase A from Streptomyces lividans.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/7915112
journal: Biochem J
volume: 302
pages: 291-5
published year: 1994
authors:
  item: Moreau A
  item: Roberge M
  item: Manin C
  item: Shareck F
  item: Kluepfel D
  item: Morosoli R

Substrate specificity of Streptomyces beta-xylanase toward glucoxylan.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/7765032
journal: Biosci Biotechnol Biochem
volume: 58
pages: 1041-4
published year: 1994
authors:
  item: Yoshida S
  item: Satoh T
  item: Shimokawa S
  item: Oku T
  item: Ito T
  item: Kusakabe I

The xylan-degrading enzyme system.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/8000329
journal: Braz J Med Biol Res
volume: 27
pages: 1093-109
published year: 1994
authors:
  item: Ferreira-Filho EX

Increase in catalytic activity and thermostability of the xylanase A of Streptomyces lividans 1326 by site-specific mutagenesis.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/7764794
journal: Enzyme Microb Technol
volume: 16
pages: 420-4
published year: 1994
authors:
  item: Moreau A
  item: Shareck F
  item: Kluepfel D
  item: Morosoli R

Alteration of the cleavage mode and of the transglycosylation reactions of the xylanase A of Streptomyces lividans 1326 by site-directed mutagenesis of the Asn173 residue.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/8306993
journal: Eur J Biochem
volume: 219
pages: 261-6
published year: 1994
authors:
  item: Moreau A
  item: Shareck F
  item: Kluepfel D
  item: Morosoli R

Crystal structure, at 2.6-A resolution, of the Streptomyces lividans xylanase A, a member of the F family of beta-1,4-D-glycanases.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/8063693
journal: J Biol Chem
volume: 269
pages: 20811-4
published year: 1994
authors:
  item: Derewenda U
  item: Swenson L
  item: Green R
  item: Wei Y
  item: Morosoli R
  item: Shareck F
  item: Kluepfel D
  item: Derewenda ZS

http://ezcatdb.cbrc.jp/EzCatDB/reference/D00169#13
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/7729513
journal: FEBS Lett
volume: 362
pages: 281-5
published year: 1995
authors:
  item: Jenkins J
  item: Lo Leggio L
  item: Harris G
  item: Pickersgill R
title: Beta-glucosidase, beta-galactosidase, family A cellulases, family F xylanases and two barley glycanases form a superfamily of enzymes with 8-fold beta/alpha architecture and with two conserved glutamates near the carboxy-terminal ends of beta-strands four and seven.

Characterization of two important histidine residues in the active site of xylanase A from Streptomyces lividans, a family 10 glycanase.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9201919
journal: Biochemistry
volume: 36
pages: 7769-75
published year: 1997
authors:
  item: Roberge M
  item: Shareck F
  item: Morosoli R
  item: Kluepfel D
  item: Dupont C

Xylanolytic enzymes from fungi and bacteria.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9118232
journal: Crit Rev Biotechnol
volume: 17
pages: 39-67
published year: 1997
authors:
  item: Sunna A
  item: Antranikian G

http://ezcatdb.cbrc.jp/EzCatDB/reference/D00169#16
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9006940
journal: J Biol Chem
volume: 272
pages: 2942-51
published year: 1997
authors:
  item: Charnock SJ
  item: Lakey JH
  item: Virden R
  item: Hughes N
  item: Sinnott ML
  item: Hazlewood GP
  item: Pickersgill R
  item: Gilbert HJ
title: Key residues in subsite F play a critical role in the activity of Pseudomonas fluorescens subspecies cellulosa xylanase A against xylooligosaccharides but not against highly polymeric substrates such as xylan.

Calcium protects a mesophilic xylanase from proteinase inactivation and thermal unfolding.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9211898
journal: J Biol Chem
volume: 272
pages: 17523-30
published year: 1997
authors:
  item: Spurway TD
  item: Morland C
  item: Cooper A
  item: Sumner I
  item: Hazlewood GP
  item: O'Donnell AG
  item: Pickersgill RW
  item: Gilbert HJ

Endo-beta-1,4-xylanase families: differences in catalytic properties.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9335171
journal: J Biotechnol
volume: 57
pages: 151-66
published year: 1997
authors:
  item: Biely P
  item: Vrsanska M
  item: Tenkanen M
  item: Kluepfel D

Asparagine-127 of xylanase A from Streptomyces lividans, a key residue in glycosyl hydrolases of superfamily 4/7: kinetic evidence for its involvement in stabilization of the catalytic intermediate.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9194164
journal: Protein Eng
volume: 10
pages: 399-403
published year: 1997
authors:
  item: Roberge M
  item: Dupont C
  item: Morosoli R
  item: Shareck F
  item: Kluepfel D

Site-directed mutagenesis study of a conserved residue in family 10 glycanases: histidine 86 of xylanase A from Streptomyces lividans.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/9681873
journal: Protein Eng
volume: 11
pages: 399-404
published year: 1998
authors:
  item: Roberge M
  item: Shareck F
  item: Morosoli R
  item: Kluepfel D
  item: Dupont C

http://ezcatdb.cbrc.jp/EzCatDB/reference/D00169#21
type: BibliographicResource
comment: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
references: http://www.ncbi.nlm.nih.gov/pubmed/10571062
journal: FEBS Lett
volume: 460
pages: 61-6
published year: 1999
authors:
  item: Kaneko S
  item: Kuno A
  item: Fujimoto Z
  item: Shimizu D
  item: Machida S
  item: Sato Y
  item: Yura K
  item: Go M
  item: Mizuno H
  item: Taira K
  item: Kusakabe I
  item: Hayashi K
title: An investigation of the nature and function of module 10 in a family F/10 xylanase FXYN of Streptomyces olivaceoviridis E-86 by module shuffling with the Cex of Cellulomonas fimi and by site-directed mutagenesis.
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: Q7SI98

Significant enhancement in the binding of p-nitrophenyl-beta-D-xylobioside by the E128H mutant F/10 xylanase from Streptomyces olivaceoviridis E-86.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/10359093
journal: FEBS Lett
volume: 450
pages: 299-305
published year: 1999
authors:
  item: Kuno A
  item: Shimizu D
  item: Kaneko S
  item: Hasegawa T
  item: Gama Y
  item: Hayashi K
  item: Kusakabe I
  item: Taira K

Module-intron correlation and intron sliding in family F/10 xylanase genes.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/10570988
journal: Gene
volume: 238
pages: 93-101
published year: 1999
authors:
  item: Sato Y
  item: Niimura Y
  item: Yura K
  item: Go M

Characterization of active-site aromatic residues in xylanase A from Streptomyces lividans.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/10235626
journal: Protein Eng
volume: 12
pages: 251-7
published year: 1999
authors:
  item: Roberge M
  item: Shareck F
  item: Morosoli R
  item: Kluepfel D
  item: Dupont C

Crystal structure of Streptomyces olivaceoviridis E-86 beta-xylanase containing xylan-binding domain.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/10884353
journal: J Mol Biol
volume: 300
pages: 575-85
published year: 2000
authors:
  item: Fujimoto Z
  item: Kuno A
  item: Kaneko S
  item: Yoshida S
  item: Kobayashi H
  item: Kusakabe I
  item: Mizuno H

http://ezcatdb.cbrc.jp/EzCatDB/reference/D00169#26
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/10767281
journal: J Biol Chem
volume: 275
pages: 23027-33
published year: 2000
authors:
  item: Andrews SR
  item: Charnock SJ
  item: Lakey JH
  item: Davies GJ
  item: Claeyssens M
  item: Nerinckx W
  item: Underwood M
  item: Sinnott ML
  item: Warren RA
  item: Gilbert HJ
title: Substrate specificity in glycoside hydrolase family 10. Tyrosine 87 and leucine 314 play a pivotal role in discriminating between glucose and xylose binding in the proximal active site of Pseudomonas cellulosa xylanase 10A.
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl

Crystal structures of the sugar complexes of Streptomyces olivaceoviridis E-86 xylanase: sugar binding structure of the family 13 carbohydrate binding module.
type: BibliographicResource
comment: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
references: http://www.ncbi.nlm.nih.gov/pubmed/11829503
journal: J Mol Biol
volume: 316
pages: 65-78
published year: 2002
authors:
  item: Fujimoto Z
  item: Kuno A
  item: Kaneko S
  item: Kobayashi H
  item: Kusakabe I
  item: Mizuno H
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: Q7SI98

High-resolution crystal structures of the lectin-like xylan binding domain from Streptomyces lividans xylanase 10A with bound substrates reveal a novel mode of xylan binding.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/11914070
journal: Biochemistry
volume: 41
pages: 4246-54
published year: 2002
authors:
  item: Notenboom V
  item: Boraston AB
  item: Williams SJ
  item: Kilburn DG
  item: Rose DR
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl

A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/12744311
journal: Chem Commun (Camb)
pages: 944-5
published year: 2003
authors:
  item: Gloster T
  item: Williams SJ
  item: Tarling CA
  item: Roberts S
  item: Dupont C
  item: Jodoin P
  item: Shareck F
  item: Withers SG
  item: Davies GJ
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl

Structure and function of a family 10 beta-xylanase chimera of Streptomyces olivaceoviridis E-86 FXYN and Cellulomonas fimi Cex.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/15078885
journal: J Biol Chem
volume: 279
pages: 26619-26
published year: 2004
authors:
  item: Kaneko S
  item: Ichinose H
  item: Fujimoto Z
  item: Kuno A
  item: Yura K
  item: Go M
  item: Mizuno H
  item: Kusakabe I
  item: Kobayashi H

endo-(1->4)-beta-xylan 4-xylanohydrolase
type: KeggEnzyme

endo-1,4-xylanase
type: KeggEnzyme

xylanase
type: KeggEnzyme

beta-1,4-xylanase
type: KeggEnzyme

endo-1,4-xylanase
type: KeggEnzyme

endo-beta-1,4-xylanase
type: KeggEnzyme

endo-1,4-beta-D-xylanase
type: KeggEnzyme

1,4-beta-xylan xylanohydrolase
type: KeggEnzyme

beta-xylanase
type: KeggEnzyme

beta-1,4-xylan xylanohydrolase
type: KeggEnzyme

endo-1,4-beta-xylanase
type: KeggEnzyme

beta-D-xylanase
type: KeggEnzyme

Analogue
compound: Xylan
pdb: 1od8A
ligand het code: XYP-XDL

IntermediateAnalogue
pdb: 1e0vA
ligand het code: FFC

IntermediateAnalogue
pdb: 1e0xA
ligand het code: XYP-X2F

IntermediateAnalogue
pdb: 1e0xB
ligand het code: XYP-X2F

ReferenceForCatalyticMechanism
reference index: 7

ReferenceForCatalyticMechanism
reference index: 11
reference section: Fig.4

ReferenceForCatalyticMechanism
reference index: 12
reference section: p.20813

ReferenceForCatalyticMechanism
reference index: 19

ReferenceForCatalyticMechanism
reference index: 20

ReferenceForCatalyticMechanism
reference index: 22
reference section: Fig.1
reference step: 4