S00327
type: Enzyme
rlcp: p8010
cath: Rossmann fold
ec: https://purl.uniprot.org/enzyme/1.1.1.62
uniprot: P14061
uniprot: Q8NBQ5
kegg enzyme: estradiol 17beta-dehydrogenase
kegg pathway: Androgen and estrogen metabolism
kegg substrate: NAD+
kegg substrate: NADP+
kegg substrate: Estradiol-17beta
kegg product: NADH
kegg product: NADPH
kegg product: Estrone
kegg product: H+
pdb: 1a27A
pdb: 1bhsA
pdb: 1dhtA
pdb: 1equA
pdb: 1equB
pdb: 1fdsA
pdb: 1fdtA
pdb: 1fduA
pdb: 1fduB
pdb: 1fduC
pdb: 1fduD
pdb: 1fdvA
pdb: 1fdvB
pdb: 1fdvC
pdb: 1fdvD
pdb: 1fdwA
pdb: 1i5rA
pdb: 1iolA
pdb: 1jtvA
pdb: 1qyvA
pdb: 1qywA
pdb: 1qyxA
pdb: 3deyX
pdb: 3dheA
pdb: 3hb4X
pdb: 3hb5X
pdb: 3klmX
pdb: 3klpX
pdb: 3km0A
pdb: 3km0B
pdb: 1yb1A
pdb: 1yb1B
active site residues resources: Human placental estradiol 17 beta-dehydrogenase: structural and catalytic changes during urea denaturation.
active site residues resources: The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors.
active site residues resources: Human Type I 17Beta-Hydroxysteroid Dehydrogenase: Site Directed Mutagenesis and X-Ray Crystallography Structure-Function Analysis.
active site residues resources: P14061
references: NAD(P)+ analogues: tools for the investigation of the active site of oestradiol 17beta-dehydrogenase from human placenta.
references: Affinity labelling of the estradiol-17 beta dehydrogenase from human placenta with substrate analogs.
references: Steroid specificity in the stimulation of human endometrial estradiol dehydrogenase.
references: Spatial relationship of steroid and cofactor at the active site of human placental estradiol 17 beta-dehydrogenase.
references: Inactivation of human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase with active site-directed 17 beta-propynyl-substituted progestin analogs.
references: Affinity labeling of arginyl residues at the catalytic region of estradiol 17 beta-dehydrogenase from human placenta by 16-oxoestrone.
references: Photochemical inactivation of human placental estradiol 17 beta-dehydrogenase in the presence of 2,3-butanedione.
references: Human placental estradiol 17 beta-dehydrogenase: sequence of a histidine-bearing peptide in the catalytic region.
references: Chemical modification of lysine residues at active-site of human placental estradiol 17 beta-dehydrogenase.
references: Complete amino acid sequence of human placental 17 beta-hydroxysteroid dehydrogenase deduced from cDNA.
references: Preparation of 14,15-secoestra-1,3,5(10)-trien-15-ynes, inhibitors of estradiol dehydrogenase.
references: Stereospecificity of hydrogen transfer between progesterone and cofactor by human placental estradiol-17 beta dehydrogenase.
references: Hydrogen bonding in steroidogenesis: studies on new heterocyclic analogs of estrone that inhibit human estradiol 17 beta-dehydrogenase.
references: Estradiol 17 beta-dehydrogenase: full enzymatic activity in the absence of zinc.
references: Molecular cloning and amino acid sequence of the porcine 17 beta-estradiol dehydrogenase.
references: Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution.
references: Human placental estradiol 17 beta-dehydrogenase: structural and catalytic changes during urea denaturation.
references: Studies on the three-dimensional structure of estrogenic 17 beta-hydroxysteroid dehydrogenase.
references: Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol.
references: The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors.
references: Human Type I 17Beta-Hydroxysteroid Dehydrogenase: Site Directed Mutagenesis and X-Ray Crystallography Structure-Function Analysis.
references: Characterization of structural and functional properties of human 17 beta-hydroxysteroid dehydrogenase type 1 using recombinant enzymes and site-directed mutagenesis.
references: Unusual charge stabilization of NADP+ in 17beta-hydroxysteroid dehydrogenase.
references: 3D-structure of human estrogenic 17beta-HSD1: binding with various steroids.
references: Crystallization and preliminary crystal structure of the complex of 17beta-hydroxysteroid dehydrogenase with a dual-site inhibitor.
references: Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+.
references: 17Beta-hydroxysteroid dehydrogenase from Cochliobolus lunatus: model structure and substrate specificity.
references: Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17beta-hydroxysteroid dehydrogenase. C-18/c-19 steroid discrimination and enzyme-induced strain.
references: Structure-based phylogenetic analysis of short-chain alcohol dehydrogenases and reclassification of the 17beta-hydroxysteroid dehydrogenase family.

Rossmann fold
type: Cath
references: http://www.cathdb.info/version/latest/superfamily/3.40.50.720
catalytic domain: index.html

Androgen and estrogen metabolism
type: KeggPathway
references: KEGG:MAP00150

NAD+
type: KeggSubstrate
references: KEGG:C00003
references: CHEBI:15846
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi
compound type: amide group
compound type: amine group
compound type: nucleotide

NADP+
type: KeggSubstrate
references: KEGG:C00006
references: CHEBI:18009
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi
compound type: amide group
compound type: amine group
compound type: nucleotide

Estradiol-17beta
type: KeggSubstrate
references: KEGG:C00951
references: CHEBI:16469
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi
compound type: aromatic ring (only carbon atom)
compound type: carbohydrate
compound type: steroid

NADH
type: KeggProduct
references: KEGG:C00004
references: CHEBI:16908
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi
compound type: amide group
compound type: amine group
compound type: nucleotide

NADPH
type: KeggProduct
references: KEGG:C00005
references: CHEBI:16474
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi
compound type: amide group
compound type: amine group
compound type: nucleotide

Estrone
type: KeggProduct
references: KEGG:C00468
references: CHEBI:17263
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi
compound type: aromatic ring (only carbon atom)
compound type: carbohydrate
compound type: steroid

H+
type: KeggProduct
references: KEGG:C00080
references: CHEBI:15378
references: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi
compound type: others

1a27A
type: Pdb
references: 1a27
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1a27
catalytic residue: SER 142;TYR 155;LYS 159

1bhsA
type: Pdb
references: 1bhs
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1bhs
catalytic residue: SER 142;TYR 155;LYS 159

1dhtA
type: Pdb
references: 1dht
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1dht
catalytic residue: SER 142;TYR 155;LYS 159

1equA
type: Pdb
references: 1equ
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1equ
catalytic residue: SER 142;TYR 155;LYS 159

1equB
type: Pdb
references: 1equ
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1equ
catalytic residue: SER 142;TYR 155;LYS 159

1fdsA
type: Pdb
references: 1fds
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1fds
catalytic residue: SER 142;TYR 155;LYS 159

1fdtA
type: Pdb
references: 1fdt
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1fdt
catalytic residue: SER 142;TYR 155;LYS 159

1fduA
type: Pdb
references: 1fdu
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1fdu
catalytic residue: SER 142;TYR 155;LYS 159
comment: mutant H221L

1fduB
type: Pdb
references: 1fdu
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1fdu
catalytic residue: SER 142;TYR 155;LYS 159
comment: mutant H221L

1fduC
type: Pdb
references: 1fdu
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1fdu
catalytic residue: SER 142;TYR 155;LYS 159
comment: mutant H221L

1fduD
type: Pdb
references: 1fdu
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1fdu
catalytic residue: SER 142;TYR 155;LYS 159
comment: mutant H221L

1fdvA
type: Pdb
references: 1fdv
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1fdv
catalytic residue: SER 142;TYR 155;LYS 159
comment: mutant H221L

1fdvB
type: Pdb
references: 1fdv
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1fdv
catalytic residue: SER 142;TYR 155;LYS 159
comment: mutant H221L

1fdvC
type: Pdb
references: 1fdv
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1fdv
catalytic residue: SER 142;TYR 155;LYS 159
comment: mutant H221L

1fdvD
type: Pdb
references: 1fdv
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1fdv
catalytic residue: SER 142;TYR 155;LYS 159
comment: mutant H221L

1fdwA
type: Pdb
references: 1fdw
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1fdw
catalytic residue: SER 142;TYR 155;LYS 159
comment: mutant H221Q

1i5rA
type: Pdb
references: 1i5r
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1i5r
catalytic residue: SER 142;TYR 155;LYS 159

1iolA
type: Pdb
references: 1iol
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1iol
catalytic residue: SER 142;TYR 155;LYS 159

1jtvA
type: Pdb
references: 1jtv
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1jtv
catalytic residue: SER 142;TYR 155;LYS 159

1qyvA
type: Pdb
references: 1qyv
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1qyv
catalytic residue: SER 142;TYR 155;LYS 159

1qywA
type: Pdb
references: 1qyw
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1qyw
catalytic residue: SER 142;TYR 155;LYS 159

1qyxA
type: Pdb
references: 1qyx
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1qyx
catalytic residue: SER 142;TYR 155;LYS 159

3deyX
type: Pdb
references: 3dey
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:3dey
catalytic residue: SER 142;TYR 155;LYS 159

3dheA
type: Pdb
references: 3dhe
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:3dhe
catalytic residue: SER 142;TYR 155;LYS 159

3hb4X
type: Pdb
references: 3hb4
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:3hb4
catalytic residue: SER 142;TYR 155;LYS 159

3hb5X
type: Pdb
references: 3hb5
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:3hb5
catalytic residue: SER 142;TYR 155;LYS 159

3klmX
type: Pdb
references: 3klm
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:3klm
catalytic residue: SER 142;TYR 155;LYS 159

3klpX
type: Pdb
references: 3klp
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:3klp
catalytic residue: SER 142;TYR 155;LYS 159

3km0A
type: Pdb
references: 3km0
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:3km0
catalytic residue: SER 142;TYR 155;LYS 159

3km0B
type: Pdb
references: 3km0
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:3km0
catalytic residue: SER 142;TYR 155;LYS 159

1yb1A
type: Pdb
references: 1yb1
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1yb1
catalytic residue: SER 167;TYR 180;LYS 184

1yb1B
type: Pdb
references: 1yb1
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: PDB:1yb1
catalytic residue: SER 167;TYR 180;LYS 184

Human placental estradiol 17 beta-dehydrogenase: structural and catalytic changes during urea denaturation.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/8917625
journal: Biochim Biophys Acta
volume: 1297
pages: 219-27
published year: 1996
authors:
  item: Mendoza-Hernandez G
  item: Rendon JL

The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors.
type: BibliographicResource
comment: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).
medline id: 96398680
references: http://www.ncbi.nlm.nih.gov/pubmed/8805577
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: P14061
journal: Structure
volume: 4
pages: 905-15
published year: 1996
authors:
  item: Breton R
  item: Housset D
  item: Mazza C
  item: Fontecilla-Camps JC

Human Type I 17Beta-Hydroxysteroid Dehydrogenase: Site Directed Mutagenesis and X-Ray Crystallography Structure-Function Analysis.
type: BibliographicResource
comment: X-ray crystallography
journal: Grenoble : Universite Joseph Fourier (Thesis)
published year: 1997
authors:
  item: Mazza
  item: C
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl

NAD(P)+ analogues: tools for the investigation of the active site of oestradiol 17beta-dehydrogenase from human placenta.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/240714
journal: Eur J Biochem
volume: 56
pages: 557-61
published year: 1975
authors:
  item: Biellmann JF
  item: Hirth CG

Affinity labelling of the estradiol-17 beta dehydrogenase from human placenta with substrate analogs.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/976263
journal: Eur J Biochem
volume: 68
pages: 385-94
published year: 1976
authors:
  item: Pons M
  item: Nicolas JC
  item: Boussioux AM
  item: Descomps B
  item: Crastes de Paulet A

Steroid specificity in the stimulation of human endometrial estradiol dehydrogenase.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/570483
journal: Endocrinology
volume: 102
pages: 1398-1403
published year: 1978
authors:
  item: Tseng L

Spatial relationship of steroid and cofactor at the active site of human placental estradiol 17 beta-dehydrogenase.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/6949898
journal: J Biol Chem
volume: 257
pages: 2225-9
published year: 1982
authors:
  item: Chin CC
  item: Pineda J
  item: Warren JC

Inactivation of human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase with active site-directed 17 beta-propynyl-substituted progestin analogs.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/6949900
journal: J Biol Chem
volume: 257
pages: 2783-6
published year: 1982
authors:
  item: Tobias B
  item: Covey DF
  item: Strickler RC

Affinity labeling of arginyl residues at the catalytic region of estradiol 17 beta-dehydrogenase from human placenta by 16-oxoestrone.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/6572146
journal: Eur J Biochem
volume: 129
pages: 691-5
published year: 1983
authors:
  item: Inano H
  item: Tamaoki B

Photochemical inactivation of human placental estradiol 17 beta-dehydrogenase in the presence of 2,3-butanedione.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/6580513
journal: J Steroid Biochem
volume: 19
pages: 1617-22
published year: 1983
authors:
  item: Inano H
  item: Ohba H
  item: Tamaoki B

Human placental estradiol 17 beta-dehydrogenase: sequence of a histidine-bearing peptide in the catalytic region.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/3456799
journal: Biochemistry
volume: 25
pages: 641-6
published year: 1986
authors:
  item: Murdock GL
  item: Chin CC
  item: Warren JC

Chemical modification of lysine residues at active-site of human placental estradiol 17 beta-dehydrogenase.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/3130054
journal: Biochem Biophys Res Commun
volume: 152
pages: 789-93
published year: 1988
authors:
  item: Inano H

Complete amino acid sequence of human placental 17 beta-hydroxysteroid dehydrogenase deduced from cDNA.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/2846351
journal: FEBS Lett
volume: 239
pages: 73-7
published year: 1988
authors:
  item: Peltoketo H
  item: Isomaa V
  item: Maentausta O
  item: Vihko R

Preparation of 14,15-secoestra-1,3,5(10)-trien-15-ynes, inhibitors of estradiol dehydrogenase.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/2772972
journal: Steroids
volume: 53
pages: 77-96
published year: 1989
authors:
  item: Auchus RJ
  item: Palmer JO
  item: Carrell HL
  item: Covey DF

Stereospecificity of hydrogen transfer between progesterone and cofactor by human placental estradiol-17 beta dehydrogenase.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/2146972
journal: J Steroid Biochem Mol Biol
volume: 37
pages: 65-70
published year: 1990
authors:
  item: Pineda JA
  item: Murdock GL
  item: Watson RJ
  item: Warren JC

Hydrogen bonding in steroidogenesis: studies on new heterocyclic analogs of estrone that inhibit human estradiol 17 beta-dehydrogenase.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/1953709
journal: Biochem Biophys Res Commun
volume: 180
pages: 1057-63
published year: 1991
authors:
  item: Sweet F
  item: Boyd J
  item: Medina O
  item: Konderski L
  item: Murdock GL

Estradiol 17 beta-dehydrogenase: full enzymatic activity in the absence of zinc.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/1998720
journal: Biochim Biophys Acta
volume: 1076
pages: 197-202
published year: 1991
authors:
  item: Murdock GL
  item: Pineda J
  item: Nagorsky N
  item: Lawrence SS
  item: Heritage R
  item: Warren JC

Molecular cloning and amino acid sequence of the porcine 17 beta-estradiol dehydrogenase.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/8200347
journal: Eur J Biochem
volume: 222
pages: 221-7
published year: 1994
authors:
  item: Leenders F
  item: Adamski J
  item: Husen B
  item: Thole HH
  item: Jungblut PW

Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution.
type: BibliographicResource
comment: X-RAY CRYSTALLOGRAPHY (2.2 AND 1.7 ANGSTROMS).
medline id: 95393021
references: http://www.ncbi.nlm.nih.gov/pubmed/7663947
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: P14061
journal: Structure
volume: 3
pages: 503-13
published year: 1995
authors:
  item: Ghosh D
  item: Pletnev VZ
  item: Zhu DW
  item: Wawrzak Z
  item: Duax WL
  item: Pangborn W
  item: Labrie F
  item: Lin SX

Studies on the three-dimensional structure of estrogenic 17 beta-hydroxysteroid dehydrogenase.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/8943782
journal: J Endocrinol
volume: 150 Suppl
pages: S13-20
published year: 1996
authors:
  item: Lin SX
  item: Zhu DW
  item: Azzi A
  item: Campbell RL
  item: Breton R
  item: Labrie F
  item: Ghosh D
  item: Pletnev V
  item: Duax WL
  item: Pangborn W

Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol.
type: BibliographicResource
comment: X-ray crystallography
references: http://www.ncbi.nlm.nih.gov/pubmed/8756321
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
journal: Nat Struct Biol
volume: 3
pages: 665-8
published year: 1996
authors:
  item: Azzi A
  item: Rehse PH
  item: Zhu DW
  item: Campbell RL
  item: Labrie F
  item: Lin SX

Characterization of structural and functional properties of human 17 beta-hydroxysteroid dehydrogenase type 1 using recombinant enzymes and site-directed mutagenesis.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/8994190
journal: Mol Endocrinol
volume: 11
pages: 77-86
published year: 1997
authors:
  item: Puranen T
  item: Poutanen M
  item: Ghosh D
  item: Vihko P
  item: Vihko R

Unusual charge stabilization of NADP+ in 17beta-hydroxysteroid dehydrogenase.
type: BibliographicResource
comment: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
medline id: 98192605
references: http://www.ncbi.nlm.nih.gov/pubmed/9525918
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
references: P14061
journal: J Biol Chem
volume: 273
pages: 8145-52
published year: 1998
authors:
  item: Mazza C
  item: Breton R
  item: Housset D
  item: Fontecilla-Camps JC

3D-structure of human estrogenic 17beta-HSD1: binding with various steroids.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/10419021
journal: J Steroid Biochem Mol Biol
volume: 69
pages: 425-9
published year: 1999
authors:
  item: Lin SX
  item: Han Q
  item: Azzi A
  item: Zhu DW
  item: Gangloff A
  item: Campbell RL
  item: Gongloff A

Crystallization and preliminary crystal structure of the complex of 17beta-hydroxysteroid dehydrogenase with a dual-site inhibitor.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/10622412
journal: J Steroid Biochem Mol Biol
volume: 70
pages: 229-35
published year: 1999
authors:
  item: Zhu DW
  item: Campbell R
  item: Labrie F
  item: Lin SX

Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+.
type: BibliographicResource
comment: X-ray crystallography
references: http://www.ncbi.nlm.nih.gov/pubmed/9927655
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
journal: Proc Natl Acad Sci U S A
volume: 96
pages: 840-5
published year: 1999
authors:
  item: Sawicki MW
  item: Erman M
  item: Puranen T
  item: Vihko P
  item: Ghosh D

17Beta-hydroxysteroid dehydrogenase from Cochliobolus lunatus: model structure and substrate specificity.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/11368312
journal: Arch Biochem Biophys
volume: 384
pages: 255-62
published year: 2000
authors:
  item: Rizner TL
  item: Adamski J
  item: Stojan J

Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17beta-hydroxysteroid dehydrogenase. C-18/c-19 steroid discrimination and enzyme-induced strain.
type: BibliographicResource
comment: X-RAY CRYSTALLOGRAPHY (2.24 ANGSTROMS) OF 38-327, AND MUTAGENESIS OF LEU-149.
references: http://www.ncbi.nlm.nih.gov/pubmed/10625652
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
journal: J Biol Chem
volume: 275
pages: 1105-11
published year: 2000
authors:
  item: Han Q
  item: Campbell RL
  item: Gangloff A
  item: Huang YW
  item: Lin SX

Structure-based phylogenetic analysis of short-chain alcohol dehydrogenases and reclassification of the 17beta-hydroxysteroid dehydrogenase family.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/11719564
journal: Mol Biol Evol
volume: 18
pages: 2154-61
published year: 2001
authors:
  item: Breitling R
  item: Laubner D
  item: Adamski J

Critical residues for the specificity of cofactors and substrates in human estrogenic 17beta-hydroxysteroid dehydrogenase 1: variants designed from the three-dimensional structure of the enzyme.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/11682630
journal: Mol Endocrinol
volume: 15
pages: 2010-20
published year: 2001
authors:
  item: Huang YW
  item: Pineau I
  item: Chang HJ
  item: Azzi A
  item: Bellemare V
  item: Laberge S
  item: Lin SX

Structure of bacterial 3beta/17beta-hydroxysteroid dehydrogenase at 1.2 A resolution: a model for multiple steroid recognition.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/12475215
journal: Biochemistry
volume: 41
pages: 14659-68
published year: 2002
authors:
  item: Benach J
  item: Filling C
  item: Oppermann UC
  item: Roversi P
  item: Bricogne G
  item: Berndt KD
  item: Jornvall H
  item: Ladenstein R

A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity.
type: BibliographicResource
comment: X-ray crystallography
references: http://www.ncbi.nlm.nih.gov/pubmed/12223444
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
journal: FASEB J
volume: 16
pages: 1829-31
published year: 2002
authors:
  item: Qiu W
  item: Campbell RL
  item: Gangloff A
  item: Dupuis P
  item: Boivin RP
  item: Tremblay MR
  item: Poirier D
  item: Lin SX

17-beta-Hydroxysteroid dehydrogenase type 1: computational design of active site inhibitors targeted to the Rossmann fold.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/12604234
journal: Chem Biol Interact
volume: 143-144
pages: 481-91
published year: 2003
authors:
  item: Brown WM
  item: Metzger LE
  item: Barlow JP
  item: Hunsaker LA
  item: Deck LM
  item: Royer RE
  item: Vander Jagt DL

Pseudo-symmetry of C19 steroids, alternative binding orientations, and multispecificity in human estrogenic 17beta-hydroxysteroid dehydrogenase.
type: BibliographicResource
comment: X-ray crystallography
references: http://www.ncbi.nlm.nih.gov/pubmed/12490543
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
journal: FASEB J
volume: 17
pages: 274-6
published year: 2003
authors:
  item: Gangloff A
  item: Shi R
  item: Nahoum V
  item: Lin SX

http://ezcatdb.cbrc.jp/EzCatDB/reference/S00327#35
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/15110763
journal: Biochem Biophys Res Commun
volume: 318
pages: 131-4
published year: 2004
authors:
  item: Owen CP
  item: Ahmed S
title: The derivation of a potential transition state for the reduction reaction catalysed by 17beta-hydroxysteroid dehydrogenase--an approximate representation of its active site for use in drug design and discovery.

Cofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientation.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/14966133
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
journal: J Biol Chem
volume: 279
pages: 16778-85
published year: 2004
authors:
  item: Shi R
  item: Lin SX

Structure and function of human 17beta-hydroxysteroid dehydrogenases.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/16414178
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
journal: Mol Cell Endocrinol
volume: 248
pages: 61-71
published year: 2006
authors:
  item: Lukacik P
  item: Kavanagh KL
  item: Oppermann U

Binary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/19929851
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
journal: Biochem J
volume: 424
pages: 357-66
published year: 2009
authors:
  item: Mazumdar M
  item: Fournier D
  item: Zhu DW
  item: Cadot C
  item: Poirier D
  item: Lin SX

17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production.
type: BibliographicResource
references: http://www.ncbi.nlm.nih.gov/pubmed/20172961
references: http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
journal: Mol Endocrinol
volume: 24
pages: 832-45
published year: 2010
authors:
  item: Aka JA
  item: Mazumdar M
  item: Chen CQ
  item: Poirier D
  item: Lin SX

20alpha-hydroxysteroid dehydrogenase
type: KeggEnzyme

17beta,20alpha-hydroxysteroid dehydrogenase
type: KeggEnzyme

17beta-estradiol dehydrogenase
type: KeggEnzyme

estradiol dehydrogenase
type: KeggEnzyme

estrogen 17-oxidoreductase
type: KeggEnzyme

17beta-HSD
type: KeggEnzyme

Analogue
compound: NAD+
pdb: 1i5rA
ligand het code: HYC(Adenosine of NAD)

Analogue
compound: NADP+
pdb: 1qywA
ligand het code: NAP

Analogue
compound: NADP+
pdb: 1qyxA
ligand het code: NAP

Analogue
compound: Estradiol-17beta
pdb: 1dhtA
ligand het code: DHT

Analogue
compound: Estradiol-17beta
pdb: 1i5rA
ligand het code: HYC(Estradiol)

Analogue
compound: Estradiol-17beta
pdb: 1jtvA
ligand het code: TES(disoriented)

Analogue
compound: Estradiol-17beta
pdb: 3deyX
ligand het code: DHT(disoriented)

Analogue
compound: Estradiol-17beta
pdb: 3hb4X
ligand het code: E2B

Analogue
compound: Estradiol-17beta
pdb: 3hb5X
ligand het code: E2B

Analogue
compound: Estradiol-17beta
pdb: 3klmX
ligand het code: DHT(disoriented)

Analogue
compound: Estradiol-17beta
pdb: 3klpX
ligand het code: B81(disoriented)

Analogue
compound: Estradiol-17beta
pdb: 3km0A
ligand het code: AOM

Analogue
compound: Estradiol-17beta
pdb: 3km0B
ligand het code: AOM

Analogue
compound: Estrone
pdb: 1equA
ligand het code: EQI

Analogue
compound: Estrone
pdb: 1qywA
ligand het code: 5SD(disoriented)

Analogue
compound: Estrone
pdb: 1qyxA
ligand het code: ASD(disoriented)

Analogue
compound: Estrone
pdb: 3dheA
ligand het code: AND

Analogue
compound: Estrone
pdb: 1yb1A
ligand het code: AE2(disoriented)

Analogue
compound: Estrone
pdb: 1yb1B
ligand het code: AE2(disoriented)

ReferenceForCatalyticMechanism
reference index: 13
reference section: Fig.1, p.1061-1062

ReferenceForCatalyticMechanism
reference index: 14
reference section: Fig.1, p.200-201

ReferenceForCatalyticMechanism
reference index: 16
reference section: Fig.7, p.505-508

ReferenceForCatalyticMechanism
reference index: 18
reference section: Fig.5, p.S19

ReferenceForCatalyticMechanism
reference index: 19
reference section: p.667-668

ReferenceForCatalyticMechanism
reference index: 20
reference section: Fig.7, p.910-913

ReferenceForCatalyticMechanism
reference index: 26
reference section: Fig.2, p.841-842

ReferenceForCatalyticMechanism
reference index: 28
reference section: p.1109